Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.90 |
| ▸ | CASP1 | P29466 | 2/20 | 0.90 |
| ▸ | TP53 | P04637 | 2/20 | 0.90 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.90 |
| ▸ | ESR1 | P03372 | 1/20 | 0.90 |
| ▸ | PGR | P06401 | 1/20 | 0.90 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.90 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.90 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.90 |
| ▸ | HTR1A | P08908 | 1/20 | 0.90 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.90 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.90 |
| ▸ | NQO2 | P16083 | 1/20 | 0.90 |
| ▸ | MAOA | P21397 | 1/20 | 0.90 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.90 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.90 |
| ▸ | MAOB | P27338 | 1/20 | 0.90 |
| ▸ | PDE4A | P27815 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Primaquine SCHEMBL22208 | 0.95 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL29409423 | 0.95 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL12599100 | 0.95 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL22207 | 0.95 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL4959404 | 0.94 | KDM4E (0.98) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL979493 | 0.94 | KDM4E (0.98) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL6333949 | 0.94 | KDM4E (0.98) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL9240759 | 0.93 | KDM4E (0.92) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL29576219 | 0.91 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CASP1TP53 | |
| Primaquine SCHEMBL41096 | 0.91 | KDM4E (1.00) | KDM4EALDH1A1CYP1A2CASP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051323-A1 | Chloroquine drug compositions and methods for their synthesis | KOSAK KENNETH M | 2008-02-28 | — | — | US | disclosed |
| WO-2007040469-A2 | CHLOROQUINE COUPLED COMPOSITIONS AND METHODS FOR THEIR SYNTHESIS | KOSAK KEN M (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070060499-A1 | Chloroquine combination drugs and methods for their synthesis | KOSAK KENNETH M | 2007-03-15 | — | — | US | disclosed |
| US-20060040879-A1 | Chloroquine coupled nucleic acids and methods for their synthesis | KOSAK KENNETH M | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060499-A1 | Chloroquine combination drugs and methods for their synthesis | CHMP4B, CTSA, CLTA | KDM4E 2153/4885ALDH1A1 4767/4885CYP1A2 4410/4885 |
| US-20080051323-A1 | Chloroquine drug compositions and methods for their synthesis | CHMP4B, CTSA, CLTA | KDM4E 2091/4885ALDH1A1 4743/4885CYP1A2 4412/4885 |
| US-20060040879-A1 | Chloroquine coupled nucleic acids and methods for their synthesis | TLR9, TLR3, EXOSC5 | KDM4E 3418/4885ALDH1A1 4696/4885CYP1A2 4743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.