Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | DHPS | P49366 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10812631 | 0.86 | KMT2A (0.73) | HSD17B10MAPTGAAMAPK1KMT2A | |
| SCHEMBL9795045 | 0.86 | HDAC1 (0.50) | HSD17B10GAAKMT2AMEN1NPC1 | |
| SCHEMBL9132310 | 0.86 | MEN1 (0.50) | HSD17B10KMT2AMEN1NPC1MRGPRX1 | |
| SCHEMBL9129235 | 0.86 | MEN1 (0.50) | HSD17B10KMT2AMEN1NPC1MRGPRX1 | |
| SCHEMBL9130935 | 0.85 | NR4A2 (0.53) | HSD17B10KMT2AMEN1NPC1MRGPRX1 | |
| SCHEMBL9795043 | 0.85 | HDAC1 (0.52) | HSD17B10GAAKMT2AMEN1NPC1 | |
| SCHEMBL9131919 | 0.85 | MEN1 (0.49) | HSD17B10KMT2AMEN1NPC1MRGPRX1 | |
| SCHEMBL9132823 | 0.84 | DHPS (0.50) | HSD17B10GAAKMT2AMEN1NPC1 | |
| SCHEMBL9130225 | 0.83 | NPC1 (0.47) | HSD17B10KMT2AMEN1NPC1MRGPRX1 | |
| SCHEMBL9131833 | 0.83 | KMT2A (0.47) | HSD17B10KMT2AMEN1NPC1MRGPRX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0213984-B1 | INDOLE CARBOXAMIDE DERIVATIVES, THEIR SALTS, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1991-01-09 | — | — | EP | disclosed |
| EP-0213984-A1 | Indole carboxamide derivatives, their salts, process and intermediates for their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1987-03-11 | — | — | EP | disclosed |