Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.44 |
| ▸ | GABRE | P78334 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.44 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15076721 | 0.79 | HSD11B1 (0.50) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| Bicarbonate SCHEMBL9497728 | 0.75 | CA2 (0.47) | TSHRCHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL1158843 | 0.71 | HSD11B1 (0.47) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL700681 | 0.71 | CHRNB2 (0.84) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL700886 | 0.71 | CHRNB2 (0.84) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Cyclopropane Carboxylic Acid SCHEMBL2952690 | 0.69 | CHRNB2 (0.57) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Cyclopropane Carboxylic Acid SCHEMBL3169412 | 0.68 | CHRNB2 (0.55) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL700682 | 0.67 | TSHR (0.46) | TSHRGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL6620534 | 0.66 | TSHR (0.60) | TSHRGABRPGABRDGABRA1GABRB1 | |
| Isonipecotic Acid SCHEMBL2027408 | 0.64 | TSHR (1.00) | TSHRGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037849-A | For treatment of heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1991-08-06 | — | — | US | disclosed |