Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | FBP1 | P09467 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL9795315 | 1.00 | RAB9A (0.40) | RAB9AATMALDH1A1HTTCYP19A1 | |
| SCHEMBL9795469 | 0.79 | CYP19A1 (0.47) | CYP19A1SMN1; SMN2CYP3A4 | |
| SCHEMBL9795472 | 0.79 | CYP19A1 (0.47) | CYP19A1SMN1; SMN2CYP3A4 | |
| Nitric Acid SCHEMBL10583881 | 0.74 | FBP1 (0.40) | RAB9AATMALDH1A1HTTCYP19A1 | |
| Nitric Acid SCHEMBL10583883 | 0.74 | FBP1 (0.40) | RAB9AATMALDH1A1HTTCYP19A1 | |
| SCHEMBL6227295 | 0.70 | CYP19A1 (0.51) | RAB9AATMALDH1A1HTTCYP19A1 | |
| SCHEMBL10361474 | 0.70 | HSP90AA1 (0.49) | CYP19A1MAPTCYP3A4HSP90AA1KMT2A | |
| Hydrochloric Acid SCHEMBL9792757 | 0.69 | HSP90AA1 (0.48) | CYP19A1MAPTCYP3A4HSP90AA1KMT2A | |
| SCHEMBL11563987 | 0.68 | CYP19A1 (0.47) | ALDH1A1HTTCYP19A1LMNAPOLB | |
| SCHEMBL9367751 | 0.67 | CYP19A1 (0.46) | RAB9AATMALDH1A1HTTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5032607-A | Enzyme inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-07-16 | — | — | US | disclosed |
| US-4866086-A | PHENYLTRIAZOLYL OLEFINIC AROMATASE INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-09-12 | — | — | US | disclosed |