Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 6/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6227295 | 0.83 | CYP19A1 (0.51) | CYP19A1CYP3A4KMT2AHSP90AA1MEN1 | |
| SCHEMBL10709515 | 0.83 | CYP19A1 (0.55) | CYP19A1CYP3A4KMT2AHSP90AA1MEN1 | |
| SCHEMBL11196779 | 0.82 | CYP19A1 (0.58) | CYP19A1CYP3A4KMT2AHSP90AA1MEN1 | |
| SCHEMBL10799731 | 0.80 | CYP19A1 (0.48) | CYP19A1CYP3A4KMT2AHSP90AA1MEN1 | |
| SCHEMBL10467330 | 0.79 | KMT2A (0.52) | CYP19A1CYP3A4KMT2AHSP90AA1MEN1 | |
| SCHEMBL10418945 | 0.79 | HSP90AA1 (0.48) | CYP19A1CYP3A4KMT2AHSP90AA1MEN1 | |
| SCHEMBL11001324 | 0.77 | KMT2A (0.79) | CYP19A1CYP3A4KMT2AHSP90AA1MEN1 | |
| SCHEMBL10364784 | 0.77 | KMT2A (0.54) | CYP19A1CYP3A4KMT2AHSP90AA1MEN1 | |
| SCHEMBL9876679 | 0.77 | KMT2A (0.46) | CYP19A1CYP3A4KMT2AHSP90AA1MEN1 | |
| SCHEMBL10764624 | 0.76 | CYP3A4 (0.50) | CYP19A1CYP3A4KMT2AHSP90AA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106397344-A | Synthetic method of fluconazole drug intermediate 2,4-dichloro-alpha-(1H-1,2,4-triazol-1-yl)acetophenone | 厦门市凯尔利信息科技有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-106397344-A | Synthetic method of fluconazole drug intermediate 2,4-dichloro-alpha-(1H-1,2,4-triazol-1-yl)acetophenone | 厦门市凯尔利信息科技有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-105541739-A | Synthetic method of fluconazole drug intermediate 2,4-dichloro-alpha-(1H-1,2,4-triazol-1-yl)acetophenone | CHENGDU QIESITE TECH CO LTD | 2016-05-04 | — | — | CN | disclosed |
| CN-105541739-A | Synthetic method of fluconazole drug intermediate 2,4-dichloro-alpha-(1H-1,2,4-triazol-1-yl)acetophenone | CHENGDU QIESITE TECH CO LTD | 2016-05-04 | — | — | CN | disclosed |
| US-5032607-A | Enzyme inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-07-16 | — | — | US | disclosed |
| EP-0411718-A2 | Thiazole derivatives, their preparation and their use as fungicides | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1991-02-06 | — | — | EP | disclosed |
| US-4925863-A | 1,3-DI(1,2,4-TRIAZOL-1-YL)-2-PROPANOL DERIVATIVES SUBSTITUTED WITH A STYRYL GROUP | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| US-4866086-A | PHENYLTRIAZOLYL OLEFINIC AROMATASE INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-09-12 | — | — | US | disclosed |
| EP-0299683-A2 | Heterocyclic olefinic compounds and their use as aromatase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-01-18 | — | — | EP | disclosed |
| EP-0235877-A1 | Triazolyl butanoic acid derivatives, process for their preparation and their use as plant growth regulators | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-09-09 | — | — | EP | disclosed |
| EP-0174769-A1 | Antifungal azole compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-03-19 | — | — | EP | disclosed |
| EP-0173807-A1 | Triazolylacyloxy ethanes, fungicide containing the same as an active ingredient and method of controlling fungi using the same | MITSUBISHI KASEI CORPORATION (JP) | 1986-03-12 | — | — | EP | disclosed |
| EP-0044605-B1 | FUNGICIDAL BIS-AZOLYL COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-02-12 | — | — | EP | disclosed |
| US-4523019-A | INTERMEDIATE FOR FUNGICIDE AND PLANT GROWTH REGULATOR | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-06-11 | — | — | US | disclosed |
| EP-0122693-A1 | Antifungal di(azolyl)propanol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-10-24 | — | — | EP | disclosed |
| EP-0111658-A2 | 1,3-Dihalopropan-2-ols | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-06-27 | — | — | EP | disclosed |
| US-4435411-A | Combating fungi with 1-phenyl-2-(1,2,4-triazol-1-yl)-prop-2-en-1-ones | BAYER AKTIENGESELLSCHAFT (DE) | 1984-03-06 | — | — | US | disclosed |
| US-4416682-A | 1,3-Bis(azolyl)propanols as fungicides and plant growth regulators | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-11-22 | — | — | US | disclosed |
| EP-0044605-A1 | Fungicidal bis-azolyl compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-01-27 | — | — | EP | disclosed |
| EP-0040367-A1 | Substituted phenyl-triazolyl-vinyl ketones, process for their preparation and their application as fungicides | BAYER AG (DE) | 1981-11-25 | — | — | EP | disclosed |