Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.61 |
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16162343 | 0.85 | ALDH1A1 (0.65) | ALDH1A1MAPTPTGS2NPSR1LMNA | |
| SCHEMBL12443641 | 0.81 | MAPT (0.69) | ALDH1A1MAPTPTGS2NPSR1LMNA | |
| SCHEMBL9615741 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPTPTGS2NPSR1LMNA | |
| SCHEMBL27940169 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MAPTPTGS2NPSR1LMNA | |
| SCHEMBL2978401 | 0.79 | ALDH1A1 (0.71) | ALDH1A1MAPTPTGS2NPSR1LMNA | |
| SCHEMBL14194286 | 0.79 | ALDH1A1 (0.58) | ALDH1A1MAPTPTGS2NPSR1LMNA | |
| SCHEMBL13344784 | 0.77 | ALDH1A1 (0.56) | ALDH1A1MAPTPTGS2NPSR1LMNA | |
| SCHEMBL31642640 | 0.77 | ALDH1A1 (0.69) | ALDH1A1MAPTNPSR1LMNATP53 | |
| SCHEMBL8177086 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MAPTNPSR1LMNATP53 | |
| SCHEMBL3165110 | 0.75 | ALDH1A1 (0.66) | ALDH1A1MAPTNPSR1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990523-A | Treatment of chronic inflammatory joint disease with arylsulfonamides | A. H. ROBINS COMPANY, INCORPORATED (US) | 1991-02-05 | — | — | US | disclosed |
| WO-1990015600-A2 | TREATMENT OF CHRONIC INFLAMMATORY JOINT DISEASE WITH ARYLSULFONAMIDES | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-12-27 | — | — | WO | disclosed |