Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.56 |
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710001 | 0.86 | ALDH1A1 (0.52) | ALDH1A1MAPTNPSR1LMNAHTT | |
| SCHEMBL17997146 | 0.82 | ALDH1A1 (0.52) | ALDH1A1MAPTNPSR1LMNAHTT | |
| SCHEMBL12443641 | 0.81 | MAPT (0.69) | ALDH1A1MAPTNPSR1LMNAHTT | |
| SCHEMBL16162343 | 0.80 | ALDH1A1 (0.65) | ALDH1A1MAPTNPSR1LMNAHTT | |
| SCHEMBL2978401 | 0.78 | ALDH1A1 (0.71) | ALDH1A1MAPTNPSR1LMNAHTT | |
| SCHEMBL9615741 | 0.77 | ALDH1A1 (0.61) | ALDH1A1MAPTNPSR1LMNAHTT | |
| SCHEMBL27940169 | 0.77 | ALDH1A1 (0.61) | ALDH1A1MAPTNPSR1LMNAHTT | |
| SCHEMBL9796248 | 0.77 | ALDH1A1 (0.61) | ALDH1A1MAPTNPSR1LMNAHTT | |
| SCHEMBL21482478 | 0.76 | ALDH1A1 (0.59) | ALDH1A1MAPTNPSR1LMNAHTT | |
| SCHEMBL21486317 | 0.75 | ALDH1A1 (0.58) | ALDH1A1MAPTNPSR1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723536-B2 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-05-25 | — | — | US | disclosed |
| US-7652031-B2 | Compounds which mimic the chemical and biological properties of discodermolide | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-01-26 | — | — | US | disclosed |
| US-20090187031-A1 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-07-23 | — | — | US | disclosed |
| US-7368585-B2 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-05-06 | — | — | US | disclosed |
| US-20070043223-A1 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043223-A1 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | LSS, DHPS, ERG28 | ALDH1A1 3187/4885MAPT 4520/4885NPSR1 2792/4885 |
| US-20090187031-A1 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof | LSS, DHPS, ERG28 | ALDH1A1 3187/4885MAPT 4520/4885NPSR1 2792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.