Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Homovanillic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.76 |
| ▸ | GAA | P10253 | 4/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.76 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | APEX1 | P27695 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | THPO | P40225 | 2/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.59 |
| ▸ | RGS12 | O14924 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 3,4-Dihydroxyphenylacetic Acid SCHEMBL8565392 | 0.89 | GAA (0.76) | TSHRGAATDP1NFKB1ALDH1A1 | |
| Dopamine SCHEMBL27902229 | 0.89 | TAAR1 (0.90) | TSHRGAATDP1NFKB1ALDH1A1 | |
| Homovanillic Acid SCHEMBL8792 | 0.87 | GAA (1.00) | TSHRGAATDP1NFKB1ALDH1A1 | |
| Homovanillic Acid SCHEMBL10535396 | 0.87 | GAA (1.00) | TSHRGAATDP1NFKB1ALDH1A1 | |
| Homovanillic Acid SCHEMBL30337229 | 0.87 | GAA (1.00) | TSHRGAATDP1NFKB1ALDH1A1 | |
| Homovanillic Acid SCHEMBL27603186 | 0.85 | GAA (0.97) | TSHRGAATDP1NFKB1ALDH1A1 | |
| SCHEMBL68386 | 0.84 | TAAR1 (1.00) | TSHRGAATDP1NFKB1ALDH1A1 | |
| SCHEMBL29365033 | 0.84 | TAAR1 (1.00) | TSHRGAATDP1NFKB1ALDH1A1 | |
| Vanillic Acid SCHEMBL28233699 | 0.84 | HTT (0.68) | TSHRGAATDP1NFKB1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL347598 | 0.82 | TAAR1 (1.00) | TSHRGAATDP1NFKB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5030636-A | Treating psychotic disorders | HOFFMANN-LA ROCHE INC. (US) | 1991-07-09 | — | — | US | disclosed |