Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | MITF | O75030 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9796583 | 0.82 | ALDH1A1 (0.39) | ALDH1A1MAPTSMN1; SMN2TP53GAA | |
| SCHEMBL9817692 | 0.81 | ALDH1A1 (0.40) | ALDH1A1MAPTSMN1; SMN2TP53GAA | |
| SCHEMBL9817615 | 0.80 | KMT2A (0.40) | ALDH1A1MAPTSMN1; SMN2TP53GAA | |
| SCHEMBL9796593 | 0.80 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2GAATSHR | |
| SCHEMBL9796449 | 0.80 | RAB9A (0.46) | ALDH1A1MAPTSMN1; SMN2GSK3BMAPK1 | |
| SCHEMBL9796279 | 0.79 | SMN1; SMN2 (0.47) | ALDH1A1MAPTSMN1; SMN2TP53GAA | |
| SCHEMBL5524626 | 0.79 | ALDH1A1 (0.48) | ALDH1A1MAPTSMN1; SMN2TP53GAA | |
| SCHEMBL9722935 | 0.78 | ALDH1A1 (0.39) | ALDH1A1MAPTSMN1; SMN2GSK3BMAPK1 | |
| SCHEMBL9796401 | 0.78 | ALDH1A1 (0.39) | ALDH1A1MAPTSMN1; SMN2GSK3BMAPK1 | |
| SCHEMBL9722950 | 0.78 | ALDH1A1 (0.38) | ALDH1A1MAPTSMN1; SMN2TP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997840-A | Quinolone sulphonates having antihypertensive activity | THE BOOTS COMPANY, PLC (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0330340-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1989-08-30 | — | — | EP | disclosed |
| WO-1989007593-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1989-08-24 | — | — | WO | disclosed |