Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MPO | P05164 | 3/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10481523 | 0.79 | KDM4E (0.52) | KDM4EGAADAOALDH1A1GLA | |
| SCHEMBL10481577 | 0.79 | KDM4E (0.54) | KDM4EGAAMPODAOMAPT | |
| SCHEMBL1349196 | 0.72 | GPR17 (0.38) | KDM4EGAADAODDO | |
| SCHEMBL10481549 | 0.72 | TP53 (0.56) | KDM4EGAAALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL29799256 | 0.70 | HTT (0.59) | KDM4EGAADAOMAPTALDH1A1 | |
| SCHEMBL5114407 | 0.70 | HTT (0.59) | KDM4EGAADAOMAPTALDH1A1 | |
| SCHEMBL10481535 | 0.70 | KDM4E (0.58) | KDM4EGAAMAPTALDH1A1HPGD | |
| SCHEMBL10481567 | 0.70 | KDM4E (0.50) | KDM4EGAAMAPTALDH1A1GLA | |
| SCHEMBL8145466 | 0.69 | PDE7A (0.47) | MPOXDHPDE7APDE7BDAO | |
| SCHEMBL10481569 | 0.69 | KDM4E (0.49) | KDM4EGAAALDH1A1GLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997840-A | Quinolone sulphonates having antihypertensive activity | THE BOOTS COMPANY, PLC (GB) | 1991-03-05 | — | — | US | disclosed |
| WO-1989007593-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1989-08-24 | — | — | WO | disclosed |