Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | CDC42 | P60953 | 1/20 | 0.57 |
| ▸ | RAC1 | P63000 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.57 |
| ▸ | PDE2A | O00408 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719875 | 0.85 | ALOX5 (0.74) | ALOX5AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL12327041 | 0.84 | ALOX5 (0.72) | ALOX5AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL9686076 | 0.83 | MMP9 (0.75) | ALOX5PDE2AMMP9TDP1 | |
| SCHEMBL9443943 | 0.81 | ALOX5 (0.68) | ALOX5AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL3724111 | 0.77 | ACACB (0.77) | ALOX5AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL24258312 | 0.76 | ALOX5 (0.60) | ALOX5AKR1C3AKR1C2PTGS2PTGS1 | |
| Hydroxyurea SCHEMBL9443929 | 0.75 | ALOX5 (0.60) | ALOX5AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL505811 | 0.75 | TDP1 (0.77) | ALOX5AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL505819 | 0.75 | TDP1 (0.77) | ALOX5AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL29403959 | 0.75 | TDP1 (0.77) | ALOX5AKR1C3AKR1C2PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068251-A | Nonsteroidal antiinflammatory agents, hydroxyurea derivatives | ABBOTT LABORATORIES (US) | 1991-11-26 | — | — | US | claimed |
| EP-0374602-A1 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-06-27 | — | — | EP | claimed |
| EP-0374602-A1 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-06-27 | — | — | EP | disclosed |