Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 9/20 | 0.40 |
| ▸ | DRD5 | P21918 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9797412 | 0.99 | SIGMAR1 (0.42) | SIGMAR1DRD1DRD5DRD2DRD3 | |
| SCHEMBL9797639 | 0.90 | SIGMAR1 (0.46) | SIGMAR1DRD1DRD5DRD2DRD3 | |
| SCHEMBL9797341 | 0.89 | DRD1 (0.49) | SIGMAR1DRD1DRD5DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9797661 | 0.89 | SIGMAR1 (0.47) | SIGMAR1DRD1DRD5DRD2DRD3 | |
| SCHEMBL9797504 | 0.88 | SLC6A2 (0.46) | SIGMAR1DRD1DRD5DRD2DRD3 | |
| Bromide SCHEMBL9797187 | 0.88 | DRD1 (0.48) | SIGMAR1DRD1DRD5DRD2DRD3 | |
| SCHEMBL9797496 | 0.84 | SLC6A2 (0.45) | SIGMAR1DRD1DRD5DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9797168 | 0.83 | SLC6A2 (0.44) | SIGMAR1DRD1DRD5DRD2DRD3 | |
| SCHEMBL10414720 | 0.80 | CYP3A4 (0.55) | DRD1DRD5DRD4MAOAMAOB | |
| SCHEMBL3697299 | 0.79 | SIGMAR1 (0.49) | SIGMAR1DRD1DRD5DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | claimed |
| US-5059688-A | 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepine preparation | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4988690-A | Antidepressants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4935418-A | Medical compositions of 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and use thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4794181-A | ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-12-27 | — | — | US | disclosed |
| EP-0096838-A1 | 1-Aryloxy-2,3,4,5-tetrahydro-3-benzazepines, a process for preparing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-12-28 | — | — | EP | disclosed |