Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | PRKX | P51817 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9860848 | 0.91 | CHEK1 (0.33) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL30688772 | 0.88 | USP8 (0.35) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL2488974 | 0.88 | USP8 (0.35) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL25523357 | 0.83 | ALDH1A1 (0.35) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL13726247 | 0.81 | ALDH1A1 (0.34) | KDM4ELMNAMAPT | |
| SCHEMBL20155734 | 0.79 | KDM4E (0.36) | KDM4ELMNA | |
| SCHEMBL19596704 | 0.78 | ALDH1A1 (0.35) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL12644360 | 0.78 | ALDH1A1 (0.35) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL23886085 | 0.76 | KDM4E (0.42) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL10087551 | 0.76 | HSD17B10 (0.38) | KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4981978-A | Reaction products of imidazole on pyrazole derivatives and 4-isopropenyl-1-cyclohexene-1-carboxaldehyde | THE DOW CHEMICAL COMPANY (US) | 1991-01-01 | — | — | US | disclosed |
| US-4831137-A | Reaction products of pteridine and 4-isopropenyl-1-cyclohexene-1-carboxaldehyde | THE DOW CHEMICAL COMPANY (US) | 1989-05-16 | — | — | US | disclosed |
| US-4755600-A | Reaction products of pyrazine, pyridine, quinoline and quinoxaline derivatives and 4-isopropenyl-1-cyclohexene-1-carboxaldehyde | THE DOW CHEMICAL COMPANY (US) | 1988-07-05 | — | — | US | disclosed |
| US-4680347-A | Thermosettable polystyrylpyrazine polymers terminated with ethylenically unsaturated groups and cured products therefrom | THE DOW CHEMICAL COMPANY (US) | 1987-07-14 | — | — | US | disclosed |
| US-4629770-A | Thermosettable polystyrylpyrazine polymers terminated with ethylenically unsaturated groups and cured products therefrom | THE DOW CHEMICAL COMPANY (US) | 1986-12-16 | — | — | US | disclosed |