Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | USP8 | P40818 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9860848 | 0.82 | CHEK1 (0.33) | KDM4EALDH1A1HTTGAAUSP8 | |
| SCHEMBL9797708 | 0.79 | CHEK1 (0.32) | KDM4ELMNA | |
| SCHEMBL30177373 | 0.76 | ALDH1A1 (0.46) | KDM4EALDH1A1HSD17B10ADRA2AADORA2A | |
| SCHEMBL13196099 | 0.76 | USP8 (0.34) | KDM4EALDH1A1HSD17B10ADRA2AADORA2A | |
| SCHEMBL23886092 | 0.76 | ALDH1A1 (0.46) | KDM4EALDH1A1HSD17B10ADRA2AADORA2A | |
| SCHEMBL17768569 | 0.74 | ALDH1A1 (0.36) | KDM4EALDH1A1HSD17B10ADRA2AADORA2A | |
| SCHEMBL25095772 | 0.74 | ALDH1A1 (0.34) | KDM4EALDH1A1HSD17B10ADRA2AADORA2A | |
| SCHEMBL507982 | 0.73 | USP8 (0.44) | KDM4EALDH1A1HTTGAAUSP8 | |
| SCHEMBL137039 | 0.73 | USP8 (0.35) | KDM4EALDH1A1HSD17B10HTTHPGD | |
| SCHEMBL29437694 | 0.73 | USP8 (0.35) | KDM4EALDH1A1HSD17B10HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210094948-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-04-01 | — | — | US | disclosed |
| US-10647713-B2 | TYK2 inhibitors and uses thereof | NIMBUS LAKSHMI, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210094948-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | KDM4E 391/4885ALDH1A1 4827/4885HSD17B10 2692/4885 |
| US-20180134700-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK2, JAK1 | KDM4E 391/4885ALDH1A1 4827/4885HSD17B10 2692/4885 |
| US-10647713-B2 | TYK2 inhibitors and uses thereof | TYK2, JAK2, JAK1 | KDM4E 391/4885ALDH1A1 4827/4885HSD17B10 2692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.