Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9797708 | 0.91 | CHEK1 (0.32) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL20155734 | 0.82 | KDM4E (0.36) | KDM4EGAAUSP8ALDH1A1HTT | |
| SCHEMBL12644360 | 0.80 | ALDH1A1 (0.35) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL25523357 | 0.80 | ALDH1A1 (0.35) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL19596704 | 0.80 | ALDH1A1 (0.35) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL23886085 | 0.78 | KDM4E (0.42) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL30019671 | 0.78 | KDM4E (0.42) | CHEK1ABL1PDGFRBPDGFRAFLT1 | |
| SCHEMBL13726247 | 0.78 | ALDH1A1 (0.34) | KDM4EUSP8USP7ALDH1A1MAPK1 | |
| SCHEMBL10924100 | 0.78 | RECQL (0.39) | KDM4EGAAUSP8USP7ALDH1A1 | |
| SCHEMBL2488974 | 0.78 | USP8 (0.35) | CHEK1ABL1PDGFRBPDGFRAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0202244-B1 | CURED PRODUCTS FROM THERMOSETTABLE POLYMERS OR PREPOLYMERS PREPARED FROM POLYMETHYLATED PYRAZINES AND AROMATIC POLYALDEHYDES | THE DOW CHEMICAL COMPANY (US) | 1991-11-21 | — | — | EP | disclosed |
| US-4543388-A | Thermosettable polymers or prepolymers prepared from polymethylated pyrazines and aromatic polyaldehydes and cured products therefrom | THE DOW CHEMICAL COMPANY (US) | 1985-09-24 | — | — | US | disclosed |