Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.37 |
| ▸ | ADH1C | P00326 | 1/20 | 0.37 |
| ▸ | ADH1A | P07327 | 1/20 | 0.37 |
| ▸ | ADH4 | P08319 | 1/20 | 0.37 |
| ▸ | ADH7 | P40394 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11655220 | 0.98 | EPHX1 (0.48) | EPHX1HPGDKMT2AEPHX2NPC1 | |
| SCHEMBL10058388 | 0.93 | — | — | |
| SCHEMBL7945281 | 0.85 | EPHX1 (0.54) | EPHX1HPGDKMT2AEPHX2NPC1 | |
| SCHEMBL1148328 | 0.85 | EPHX1 (0.54) | EPHX1HPGDKMT2AEPHX2NPC1 | |
| SCHEMBL3116167 | 0.82 | EPHX1 (0.50) | EPHX1HPGDKMT2AEPHX2NPC1 | |
| SCHEMBL11974545 | 0.80 | EPHX1 (0.56) | EPHX1HPGDKMT2AEPHX2NPC1 | |
| SCHEMBL11484764 | 0.79 | HPGD (0.41) | EPHX1HPGDKMT2AEPHX2NPC1 | |
| SCHEMBL502374 | 0.78 | EPHX1 (0.48) | EPHX1HPGDKMT2AEPHX2NPC1 | |
| SCHEMBL11078415 | 0.77 | ALDH1A1 (0.44) | EPHX1HPGDKMT2ANPC1RAB9A | |
| SCHEMBL11466260 | 0.77 | HPGD (0.50) | EPHX1HPGDKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411701-A2 | Certain imidazole compounds as transglutaminase inhibitors | MERCK & CO. INC. (US) | 1991-02-06 | — | — | EP | disclosed |
| US-4968713-A | THROMBOLYTIC OR FIBRINOLYTIC THERAPY | MERCK & CO., INC. (US) | 1990-11-06 | — | — | US | disclosed |