Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.37 |
| ▸ | NMT2 | O60551 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9798623 | 0.80 | NR2E1 (0.64) | NR2E1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL9799136 | 0.77 | ADRB2 (0.60) | NR2E1ADRB2ADRB1ADRB3KDM4E | |
| Indenolol SCHEMBL79023 | 0.77 | ADRB2 (0.56) | NR2E1ADRB2ADRB1ADRB3ALDH1A1 | |
| Indenolol SCHEMBL79021 | 0.77 | ADRB2 (0.56) | NR2E1ADRB2ADRB1ADRB3ALDH1A1 | |
| Indenolol SCHEMBL349116 | 0.76 | ADRB2 (0.57) | NR2E1ADRB2ADRB1ADRB3ALDH1A1 | |
| Indenolol SCHEMBL349114 | 0.76 | ADRB2 (0.57) | NR2E1ADRB2ADRB1ADRB3ALDH1A1 | |
| Indenolol SCHEMBL11666579 | 0.76 | ADRB2 (0.48) | NR2E1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL9799474 | 0.75 | ADRB2 (0.63) | NR2E1ADRB2ADRB1ADRB3KDM4E | |
| Indenolol SCHEMBL1650473 | 0.75 | ADRB2 (0.54) | NR2E1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL9798811 | 0.74 | ADRB2 (0.57) | POLBADRB2ADRB1ADRB3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229947-B1 | NOVEL CRYSTALLINE SALTS OF ARYLOXY-PROPANOLAMINES, THEIR PREPARATION AND THEIR USE | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1991-03-13 | — | — | EP | disclosed |
| US-4849530-A | Process for the preparation of crystalline salts or aryloxy-propanolamines | RORER PHARMACEUTICAL CORPORATION (US) | 1989-07-18 | — | — | US | disclosed |
| US-4767784-A | DIPHENYLACETATES | RORER PHARMACEUTICAL CORPORATION | 1988-08-30 | — | — | US | disclosed |