Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 6/20 | 0.63 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.63 |
| ▸ | TLR4 | O00206 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.45 |
| ▸ | MLNR | O43193 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10806729 | 0.87 | ADRB2 (0.69) | ADRB2DNM1TLR4MAPTLMNA | |
| SCHEMBL9856129 | 0.87 | ADRB2 (0.69) | ADRB2DNM1TLR4MAPTLMNA | |
| SCHEMBL9856507 | 0.87 | ADRB2 (0.69) | ADRB2DNM1TLR4MAPTLMNA | |
| SCHEMBL9798623 | 0.84 | NR2E1 (0.64) | ADRB2LMNAADRB3HTR1ASLC6A2 | |
| SCHEMBL10735041 | 0.80 | ADRB2 (0.71) | ADRB2DNM1TLR4MAPTLMNA | |
| Carazolol SCHEMBL29354289 | 0.78 | ADRB2 (1.00) | ADRB2DNM1TLR4MAPTLMNA | |
| Carazolol SCHEMBL77903 | 0.78 | ADRB2 (1.00) | ADRB2DNM1TLR4MAPTLMNA | |
| Carazolol SCHEMBL77901 | 0.78 | ADRB2 (1.00) | ADRB2DNM1TLR4MAPTLMNA | |
| Carazolol SCHEMBL6511163 | 0.78 | ADRB2 (1.00) | ADRB2DNM1TLR4MAPTLMNA | |
| Carazolol SCHEMBL7530148 | 0.77 | ADRB2 (0.98) | ADRB2DNM1TLR4MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229947-B1 | NOVEL CRYSTALLINE SALTS OF ARYLOXY-PROPANOLAMINES, THEIR PREPARATION AND THEIR USE | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1991-03-13 | — | — | EP | disclosed |
| US-4849530-A | Process for the preparation of crystalline salts or aryloxy-propanolamines | RORER PHARMACEUTICAL CORPORATION (US) | 1989-07-18 | — | — | US | disclosed |
| US-4767784-A | DIPHENYLACETATES | RORER PHARMACEUTICAL CORPORATION | 1988-08-30 | — | — | US | disclosed |