Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 10/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 10/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.60 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13249332 | 0.83 | ADRB2 (0.62) | ADRB2ADRB1LMNACYP2D6CYP1A2 | |
| SCHEMBL9798623 | 0.82 | NR2E1 (0.64) | ADRB2ADRB1LMNACYP2D6CYP1A2 | |
| SCHEMBL10782382 | 0.78 | ADRB2 (0.56) | ADRB2ADRB1LMNACYP2D6CYP1A2 | |
| SCHEMBL9799040 | 0.77 | NR2E1 (0.40) | ADRB2ADRB1LMNACYP2D6CYP1A2 | |
| SCHEMBL9799474 | 0.77 | ADRB2 (0.63) | ADRB2ADRB1LMNACYP2D6HTR1A | |
| Oxprenolol SCHEMBL16310 | 0.75 | ADRB2 (1.00) | ADRB2ADRB1LMNACYP2D6CYP1A2 | |
| Oxprenolol SCHEMBL29698472 | 0.75 | ADRB2 (1.00) | ADRB2ADRB1LMNACYP2D6CYP1A2 | |
| Oxprenolol SCHEMBL16311 | 0.75 | ADRB2 (1.00) | ADRB2ADRB1LMNACYP2D6CYP1A2 | |
| Oxprenolol SCHEMBL29698462 | 0.75 | ADRB2 (1.00) | ADRB2ADRB1LMNACYP2D6CYP1A2 | |
| Oxprenolol SCHEMBL6508035 | 0.75 | ADRB2 (1.00) | ADRB2ADRB1LMNACYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229947-B1 | NOVEL CRYSTALLINE SALTS OF ARYLOXY-PROPANOLAMINES, THEIR PREPARATION AND THEIR USE | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1991-03-13 | — | — | EP | disclosed |
| US-4849530-A | Process for the preparation of crystalline salts or aryloxy-propanolamines | RORER PHARMACEUTICAL CORPORATION (US) | 1989-07-18 | — | — | US | disclosed |
| US-4767784-A | DIPHENYLACETATES | RORER PHARMACEUTICAL CORPORATION | 1988-08-30 | — | — | US | disclosed |