Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 8/20 | 0.69 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.69 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.48 |
| ▸ | TLR4 | O00206 | 5/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.48 |
| ▸ | HTR2B | P41595 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10806729 | 1.00 | ADRB2 (0.69) | ADRB2DNM1ADRB3TLR4ADRB1 | |
| SCHEMBL9856507 | 1.00 | ADRB2 (0.69) | ADRB2DNM1ADRB3TLR4ADRB1 | |
| SCHEMBL9799474 | 0.87 | ADRB2 (0.63) | ADRB2DNM1ADRB3TLR4ADRB1 | |
| SCHEMBL10735041 | 0.84 | ADRB2 (0.71) | ADRB2DNM1ADRB3TLR4ADRB1 | |
| Carazolol SCHEMBL77901 | 0.82 | ADRB2 (1.00) | ADRB2DNM1ADRB3TLR4ADRB1 | |
| Carazolol SCHEMBL29354289 | 0.82 | ADRB2 (1.00) | ADRB2DNM1ADRB3TLR4ADRB1 | |
| Carazolol SCHEMBL6511163 | 0.82 | ADRB2 (1.00) | ADRB2DNM1ADRB3TLR4ADRB1 | |
| Carazolol SCHEMBL77903 | 0.82 | ADRB2 (1.00) | ADRB2DNM1ADRB3TLR4ADRB1 | |
| SCHEMBL11609886 | 0.82 | ADRB2 (0.47) | ADRB2DNM1ADRB3ADRB1SLC6A4 | |
| Carazolol SCHEMBL10568418 | 0.81 | ADRB2 (0.98) | ADRB2DNM1ADRB3TLR4ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5071868-A | Beta blockers, vasodilators, therapy for glaucoma | BOEHRINGER MANNHEIM GMBH (DE) | 1991-12-10 | — | — | US | disclosed |
| US-4985454-A | TREATMENT OF GLAUCOMA | BOEHRINGER MANNHEIM GMBH (DE) | 1991-01-15 | — | — | US | disclosed |
| US-4824963-A | REACTING EPICHLOROHYDRIN WITH 4-HYDROOXYCARBAZOLE, AMINATION | BOEHRINGER MANNHEIM GMBH (DE) | 1989-04-25 | — | — | US | disclosed |
| US-4697022-A | Process for the preparation of optically-active carbazole derivatives, new R- and S-carbazole derivatives and pharmaceutical compositions containing these compounds | BOEHRINGER MANNHEIM GMBH (DE) | 1987-09-29 | — | — | US | disclosed |