Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAPDH | P04406 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | CBR1 | P16152 | 3/20 | 0.47 |
| ▸ | AR | P10275 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | F12 | P00748 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL979319 | 0.88 | CASP3 (0.59) | MAOBNPC1RAB9ATP53MAPT | |
| SCHEMBL978431 | 0.85 | CASP3 (0.47) | MAOBNPC1RAB9ATP53MAPT | |
| SCHEMBL982797 | 0.81 | AKR1C3 (0.59) | AKR1C3MAOAMAOBCBR1AR | |
| SCHEMBL980671 | 0.81 | MAPK1 (0.55) | AKR1C3MAOAMAOBCBR1AR | |
| SCHEMBL983023 | 0.81 | AKR1C3 (0.48) | AKR1C3MAOAMAOBCBR1AR | |
| SCHEMBL979386 | 0.80 | AKR1C3 (0.51) | AKR1C3MAOAMAOBCBR1AR | |
| SCHEMBL978163 | 0.80 | MAOB (0.52) | AKR1C3MAOAMAOBCBR1AR | |
| SCHEMBL977891 | 0.80 | AKR1C3 (0.54) | AKR1C3MAOAMAOBCBR1AR | |
| SCHEMBL980649 | 0.80 | AKR1C3 (0.49) | AKR1C3MAOAMAOBCBR1AR | |
| SCHEMBL980408 | 0.79 | KMT2A (0.52) | AKR1C3MAOAMAOBCBR1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021522-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021522-A1 | ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7 | CASP7, CASP3, CASP6 | GAPDH 2365/4885AKR1C3 3154/4885MAOA 2101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.