Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GNPAT | O15228 | 3/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.41 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.39 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 2/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9800454 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTALOX15KDM4ETHRB | |
| SCHEMBL648867 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTALOX15KDM4ETHRB | |
| SCHEMBL9800504 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTALOX15KDM4ETHRB | |
| SCHEMBL648868 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPTALOX15KDM4ETHRB | |
| SCHEMBL12439670 | 0.82 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTALOX15KDM4ETHRB | |
| SCHEMBL16745724 | 0.79 | GNPAT (0.62) | SMN1; SMN2MAPTALOX15KDM4ETHRB | |
| SCHEMBL19100404 | 0.77 | KDM4E (0.50) | SMN1; SMN2MAPTALOX15KDM4ETHRB | |
| SCHEMBL468749 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTALOX15KDM4ETHRB | |
| SCHEMBL16748603 | 0.77 | MAPT (0.59) | SMN1; SMN2MAPTALOX15KDM4ETHRB | |
| SCHEMBL468750 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTALOX15KDM4ETHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230037-B1 | CYTOPROTECTIVE DERIVATIVES USEFUL IN ISCHEMIC DISEASES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | ITALFARMACO S.p.A. (IT) | 1991-03-06 | — | — | EP | disclosed |