Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 13/20 | 0.48 |
| ▸ | MGLL | Q99685 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9800485 | 0.83 | FAAH (0.51) | FAAHMGLLNPC1TDP1REN | |
| SCHEMBL9800450 | 0.78 | FAAH (0.53) | FAAHMGLLNPC1TDP1 | |
| SCHEMBL9800495 | 0.77 | GAA (0.52) | MEN1KMT2A | |
| SCHEMBL19618808 | 0.75 | TLR2 (0.49) | FAAHMGLLMEN1KMT2A | |
| SCHEMBL29053791 | 0.74 | ALDH1A1 (0.55) | FAAHMGLL | |
| SCHEMBL21257004 | 0.74 | ALDH1A1 (0.55) | FAAHMGLL | |
| SCHEMBL16195658 | 0.73 | PPARG (0.45) | MGLLTDP1 | |
| SCHEMBL16196137 | 0.73 | PPARG (0.45) | MGLLTDP1 | |
| SCHEMBL27591032 | 0.73 | SIRT2 (0.48) | TDP1MEN1KMT2A | |
| SCHEMBL19066563 | 0.72 | HPGD (0.50) | FAAHMGLLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0224272-B1 | PYRROLIDINYLAMIDE ESTER DERIVATIVE HAVING ANTI-PROLYL ENDOPEPTIDASE ACTIVITY, ITS SYNTHESIS AND USE AND A PHARMACEUTICAL COMPOSITION CONTAINING IT | SUNTORY LIMITED (JP) | 1991-02-06 | — | — | EP | disclosed |
| US-4757083-A | Enzyme inhibitors | SUNTORY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0224272-A1 | Pyrrolidinylamide ester derivative having anti-prolyl endopeptidase activity, its synthesis and use and a pharmaceutical composition containing it | SUNTORY LIMITED (JP) | 1987-06-03 | — | — | EP | disclosed |