Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 14/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9800485 | 0.83 | FAAH (0.51) | FAAHNPC1TDP1MGLL | |
| SCHEMBL9800487 | 0.78 | FAAH (0.48) | FAAHNPC1TDP1MGLL | |
| SCHEMBL21706782 | 0.76 | FAAH (0.54) | FAAHNPC1TDP1MGLLSMN1; SMN2 | |
| SCHEMBL26710742 | 0.76 | CCR1 (0.60) | NPC1TDP1SMN1; SMN2 | |
| SCHEMBL9501718 | 0.76 | CCR1 (0.60) | NPC1TDP1SMN1; SMN2 | |
| SCHEMBL11800230 | 0.75 | TSHR (0.64) | FAAHNPC1TDP1MGLLSMN1; SMN2 | |
| SCHEMBL26616529 | 0.75 | SMN1; SMN2 (0.58) | NPC1TDP1ALDH1A1SMN1; SMN2 | |
| Acetic Acid SCHEMBL28974131 | 0.73 | TSHR (0.60) | FAAHNPC1TDP1MGLLALDH1A1 | |
| SCHEMBL27741870 | 0.73 | FAAH (0.54) | FAAHNPC1TDP1MGLLSMN1; SMN2 | |
| SCHEMBL18631610 | 0.72 | DPP4 (0.55) | NPC1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0224272-B1 | PYRROLIDINYLAMIDE ESTER DERIVATIVE HAVING ANTI-PROLYL ENDOPEPTIDASE ACTIVITY, ITS SYNTHESIS AND USE AND A PHARMACEUTICAL COMPOSITION CONTAINING IT | SUNTORY LIMITED (JP) | 1991-02-06 | — | — | EP | disclosed |
| US-4757083-A | Enzyme inhibitors | SUNTORY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0224272-A1 | Pyrrolidinylamide ester derivative having anti-prolyl endopeptidase activity, its synthesis and use and a pharmaceutical composition containing it | SUNTORY LIMITED (JP) | 1987-06-03 | — | — | EP | disclosed |