Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GRM8 | O00222 | 1/20 | 0.40 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.34 |
| ▸ | CPN1 | P15169 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 3/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9800537 | 1.00 | SRC (0.43) | SRCPOLBTDP1SMN1; SMN2GRM8 | |
| SCHEMBL11155958 | 0.83 | SRC (0.61) | SRCPOLBTDP1SMN1; SMN2GRM8 | |
| SCHEMBL3539998 | 0.78 | SRC (0.54) | SRCPOLBTDP1SMN1; SMN2GRM8 | |
| SCHEMBL11150085 | 0.76 | SRC (0.46) | SRCPOLBTDP1SMN1; SMN2GRM8 | |
| SCHEMBL8672582 | 0.76 | SRC (0.46) | SRCPOLBTDP1SMN1; SMN2GRM8 | |
| SCHEMBL11150081 | 0.76 | SRC (0.46) | SRCPOLBTDP1SMN1; SMN2GRM8 | |
| SCHEMBL9524800 | 0.75 | MAPT (0.44) | MAPTLMNAALDH1A1 | |
| SCHEMBL8475858 | 0.73 | LMNA (0.51) | SRCSMN1; SMN2KDM4EMAPTLMNA | |
| SCHEMBL9300518 | 0.72 | ALDH1A1 (0.47) | SRCSMN1; SMN2CNR2CNR1KDM4E | |
| SCHEMBL9397132 | 0.72 | CNR2 (0.43) | SRCPOLBTDP1SMN1; SMN2GRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230037-B1 | CYTOPROTECTIVE DERIVATIVES USEFUL IN ISCHEMIC DISEASES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | ITALFARMACO S.p.A. (IT) | 1991-03-06 | — | — | EP | disclosed |
| US-4789681-A | CARDIOPROTECTIVE AGENTS | ITALFARMACO S.P.A. (IT) | 1988-12-06 | — | — | US | disclosed |
| EP-0230037-A1 | Cytoprotective derivatives useful in ischemic diseases, their preparation and compositions containing them | ITALFARMACO S.p.A. (IT) | 1987-07-29 | — | — | EP | disclosed |