SCHEMBL9800819

SCHEMBL9800819

CCCCc1ccc(-c2c(OC(=O)C3CCC(C(=O)Oc4ccc(F)c(F)c4-c4ccc(CCCC)cc4)CC3)ccc(F)c2F)cc1

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 2/20 0.40
FAAH O00519 1/20 0.40
RARB P10826 9/20 0.39
RARA P10276 2/20 0.39
RARG P13631 1/20 0.39
THRA P10827 2/20 0.36
THRB P10828 2/20 0.36
ALDH1A1 P00352 3/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
NPC1 O15118 1/20 0.35
MEN1 O00255 1/20 0.35
MAPT P10636 1/20 0.35
MTOR P42345 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9800811 0.93 ALDH1A1 (0.37) MGLLFAAHRARBRARARARG
SCHEMBL9800839 0.86 RARB (0.36) MGLLFAAHRARBRARARARG
SCHEMBL6914448 0.81 RARB (0.50) FAAHRARBRARARARGTHRA
SCHEMBL9800791 0.80 FFAR4 (0.49) MGLLFAAHRARBRARARARG
SCHEMBL9800840 0.79 NPC1 (0.36) ALDH1A1NPC1MEN1MAPTKMT2A
SCHEMBL9800804 0.77 CTRC (0.44) MGLLFAAHRARBALDH1A1NPC1
SCHEMBL10415568 0.77 RARB (0.41) MGLLFAAHRARBTHRATHRB
SCHEMBL9800787 0.76 RARB (0.40) MGLLFAAHRARBTHRATHRB
SCHEMBL9406264 0.75 RARB (0.42) FAAHRARBRARARARGTHRA
SCHEMBL22277664 0.75 SPHK1 (0.45) RARBRARARARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0249081-B1 TRANSHEXAHYDROTEREPHTALIC ACID ESTER DERIVATIVES Sato, Hisato (JP) 1991-03-13 EP disclosed
US-4946991-A Liquid ccrystals or their additives SATO HISATO (JP) 1990-08-07 US disclosed