SCHEMBL9801804

SCHEMBL9801804

Oc1ccc(-n2nnc3ccccc32)c(O)c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNMA1 Q12791 3/20 0.71
KMT2A Q03164 3/20 0.47
HSP90AA1 P07900 1/20 0.46
SMN1; SMN2 Q16637 3/20 0.45
RAB9A P51151 1/20 0.45
POLB P06746 2/20 0.44
MAPK1 P28482 1/20 0.44
ATM Q13315 1/20 0.44
RPS6KA3 P51812 1/20 0.43
TSHR P16473 2/20 0.42
DGAT1 O75907 1/20 0.41
ALDH1A1 P00352 3/20 0.41
MAPT P10636 2/20 0.41
SLC9A1 P19634 1/20 0.41
KEAP1 Q14145 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
THPO P40225 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11880576 0.87 KCNMA1 (0.71) KCNMA1KMT2AHSP90AA1SMN1; SMN2RAB9A
SCHEMBL8645601 0.84 KCNMA1 (0.67) KCNMA1KMT2ASMN1; SMN2RAB9APOLB
SCHEMBL80393 0.83 KCNMA1 (1.00) KCNMA1KMT2ASMN1; SMN2RAB9APOLB
SCHEMBL11521392 0.81 KCNMA1 (0.61) KCNMA1KMT2ASMN1; SMN2RAB9APOLB
SCHEMBL3974127 0.81 KCNMA1 (0.57) KCNMA1KMT2ASMN1; SMN2RAB9APOLB
SCHEMBL11468151 0.79 KCNMA1 (0.55) KCNMA1KMT2ASMN1; SMN2RAB9APOLB
2,4-Dihydroxybenzophenone SCHEMBL10800482 0.79 KCNMA1 (0.61) KCNMA1KMT2ASMN1; SMN2RAB9APOLB
SCHEMBL15766018 0.78 KCNMA1 (0.53) KCNMA1KMT2ASMN1; SMN2RAB9APOLB
SCHEMBL503004 0.76 KCNMA1 (0.59) KCNMA1SMN1; SMN2RAB9APOLBMAPK1
SCHEMBL8049206 0.76 KCNMA1 (0.51) KCNMA1RAB9ASLC9A1CYP4Z1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-59043061-A None JP disclosed
US-5037979-A Photochemical stabilizers for dyeable polyamide, polyacrylo-nitrile and polyester fibers CIBA-GEIGY CORPORATION (US) 1991-08-06 US disclosed
EP-0357545-A2 Cationic compounds, their preparation and their use in the photochemical stabilisation of basic dyeable polyamide polyacrylonitrile and polyester fibres CIBA-GEIGY AG (CH) 1990-03-07 EP disclosed
JP-S5943061-A STABILIZED SYNTHETIC RESIN COMPOSITION ADEKA ARGUS CHEM CO LTD 1984-03-09 JP disclosed