SCHEMBL8645601

SCHEMBL8645601

Cc1ccc(-n2nnc3ccccc32)c(O)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNMA1 Q12791 3/20 0.67
SMN1; SMN2 Q16637 3/20 0.47
TSHR P16473 2/20 0.47
GAA P10253 4/20 0.46
ALDH1A1 P00352 1/20 0.46
RAB9A P51151 3/20 0.45
NPC1 O15118 2/20 0.45
LMNA P02545 2/20 0.45
KMT2A Q03164 1/20 0.45
MGAM O43451 3/20 0.45
AMY1A P0DUB6 3/20 0.45
SI P14410 3/20 0.45
MGAM2 Q2M2H8 3/20 0.45
POLB P06746 3/20 0.44
SLC9A1 P19634 2/20 0.42
MAPK1 P28482 1/20 0.42
ATM Q13315 1/20 0.42
KEAP1 Q14145 1/20 0.42
KDM4E B2RXH2 1/20 0.41
RECQL P46063 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29845601 0.88 KCNMA1 (0.67) KCNMA1SMN1; SMN2TSHRGAAALDH1A1
SCHEMBL890612 0.88 KCNMA1 (0.67) KCNMA1SMN1; SMN2TSHRGAAALDH1A1
SCHEMBL13772814 0.84 KCNMA1 (0.57) KCNMA1SMN1; SMN2TSHRGAAALDH1A1
SCHEMBL9801804 0.84 KCNMA1 (0.71) KCNMA1SMN1; SMN2TSHRALDH1A1RAB9A
SCHEMBL24060749 0.84 KCNMA1 (0.53) KCNMA1SMN1; SMN2TSHRGAAALDH1A1
SCHEMBL25873798 0.82 KCNMA1 (0.50) KCNMA1SMN1; SMN2TSHRGAAALDH1A1
SCHEMBL13772823 0.82 KCNMA1 (0.50) KCNMA1SMN1; SMN2TSHRGAAALDH1A1
SCHEMBL11521392 0.81 KCNMA1 (0.61) KCNMA1SMN1; SMN2TSHRGAAALDH1A1
SCHEMBL80393 0.80 KCNMA1 (1.00) KCNMA1SMN1; SMN2TSHRGAAALDH1A1
SCHEMBL25874452 0.79 KCNMA1 (0.50) KCNMA1SMN1; SMN2TSHRGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10059987-A None JP disclosed
JP-H1059987-A DERIVATIVE OF 2-OXYPHENYLBENZOTRIAZOLE DIPHENYLPHOSPHINATE, UV ABSORBER AND RESIN COMPOSITION CONTAINING THE SAME NIPPON PAINT CO LTD 1998-03-03 JP disclosed