Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8757520 | 1.00 | TSHR (0.40) | TSHRALDH1A1TDP1USP2HPGD | |
| SCHEMBL9801863 | 1.00 | TSHR (0.40) | TSHRALDH1A1TDP1USP2HPGD | |
| SCHEMBL8403328 | 0.98 | ALDH1A1 (0.37) | TSHRALDH1A1TDP1USP2HPGD | |
| SCHEMBL11711810 | 0.82 | EPHX2 (0.41) | TSHRTDP1NPSR1PKMSMN1; SMN2 | |
| SCHEMBL4934443 | 0.82 | EPHX2 (0.41) | TSHRTDP1NPSR1PKMSMN1; SMN2 | |
| SCHEMBL8756382 | 0.82 | EPHX2 (0.41) | TSHRTDP1NPSR1PKMSMN1; SMN2 | |
| SCHEMBL8987951 | 0.80 | MEN1 (0.41) | NPSR1LMNAPKMSMN1; SMN2 | |
| SCHEMBL4821584 | 0.78 | MEN1 (0.42) | TSHRALDH1A1HPGDMAPTGAA | |
| SCHEMBL9310464 | 0.77 | NPSR1 (0.56) | TSHRALDH1A1TDP1USP2HPGD | |
| SCHEMBL9806367 | 0.76 | EPHX2 (0.41) | ALDH1A1TDP1HPGDMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0228045-B1 | AROMATIC THIOETHERS | CIBA-GEIGY AG (CH) | 1991-04-03 | — | — | EP | disclosed |
| US-4785004-A | ANTIALLERGENS, ANTIHISTAMINES | CIBA-GEIGY CORPORATION (US) | 1988-11-15 | — | — | US | disclosed |
| EP-0228045-A2 | Aromatic thioethers | CIBA-GEIGY AG (CH) | 1987-07-08 | — | — | EP | disclosed |