Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.49 |
| ▸ | CYSLTR2 | Q9NS75 | 9/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.43 |
| ▸ | BID | P55957 | 3/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.42 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.42 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL15541515 | 1.00 | LIPG (0.49) | LIPGCYSLTR2CYSLTR1BIDMCL1 | |
| Hydrochloric Acid SCHEMBL20478149 | 0.97 | LIPG (0.49) | LIPGCYSLTR2CYSLTR1BIDMCL1 | |
| Benzene SCHEMBL8729420 | 0.82 | LIPG (0.67) | LIPGCYSLTR2CYSLTR1BIDMCL1 | |
| Bromide SCHEMBL723729 | 0.81 | LIPG (0.53) | LIPGCYSLTR2CYSLTR1BIDMCL1 | |
| Bromide SCHEMBL15541520 | 0.80 | LIPG (0.43) | LIPGCYSLTR2CYSLTR1BIDMCL1 | |
| Bromide SCHEMBL10383978 | 0.80 | LTA4H (0.36) | LIPG | |
| Bromide SCHEMBL9801931 | 0.80 | HTR2A (0.54) | LIPG | |
| Bromide SCHEMBL10786925 | 0.80 | HTR2A (0.54) | LIPG | |
| Bromide SCHEMBL9802080 | 0.80 | HTR2A (0.54) | LIPG | |
| Bromide SCHEMBL2446627 | 0.80 | HIF1A (0.55) | TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0225602-B1 | ALPHA-HYDROXYTHIO ETHERS | CIBA-GEIGY AG (CH) | 1991-10-09 | — | — | EP | disclosed |
| EP-0228045-B1 | AROMATIC THIOETHERS | CIBA-GEIGY AG (CH) | 1991-04-03 | — | — | EP | disclosed |
| US-4808572-A | ANTIALLERGENS | CIBA-GEIGY CORPORATION (US) | 1989-02-28 | — | — | US | disclosed |
| US-4785004-A | ANTIALLERGENS, ANTIHISTAMINES | CIBA-GEIGY CORPORATION (US) | 1988-11-15 | — | — | US | disclosed |
| EP-0228045-A2 | Aromatic thioethers | CIBA-GEIGY AG (CH) | 1987-07-08 | — | — | EP | disclosed |
| EP-0225602-A2 | Alpha-hydroxythio ethers | CIBA-GEIGY AG (CH) | 1987-06-16 | — | — | EP | disclosed |