Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 6/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9803418 | 0.98 | SMN1; SMN2 (0.61) | SMN1; SMN2ALOX15ALDH1A1MAPTPTK2 | |
| SCHEMBL5462185 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2ALOX15ALDH1A1MAPTPTK2 | |
| SCHEMBL23537463 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2ALOX15ALDH1A1MAPTPTK2 | |
| SCHEMBL23537289 | 0.81 | SMN1; SMN2 (0.38) | SMN1; SMN2ALOX15ALDH1A1MAPTPTK2 | |
| SCHEMBL21963156 | 0.78 | ALOX15 (0.91) | SMN1; SMN2ALOX15ALDH1A1MAPTTSHR | |
| SCHEMBL9802964 | 0.73 | PTK2 (0.59) | SMN1; SMN2ALOX15ALDH1A1MAPTPTK2 | |
| SCHEMBL23537356 | 0.69 | PARP1 (0.59) | SMN1; SMN2ALOX15ALDH1A1MAPTPTK2 | |
| SCHEMBL29824193 | 0.69 | PARP1 (0.59) | SMN1; SMN2ALOX15ALDH1A1MAPTPTK2 | |
| SCHEMBL23537608 | 0.67 | DYRK1A (0.44) | PTK2TSHRDYRK1AL3MBTL1PARP1 | |
| SCHEMBL3109830 | 0.67 | ALDH1A1 (1.00) | SMN1; SMN2ALOX15ALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068334-A | Analgesics and antipyretics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |
| EP-0338228-A2 | Use of quinoline-2,5-diones in a medicament having an analgesic, antipyretic and/or antiphlogistic activity | Dr. Karl Thomae GmbH (DE) | 1989-10-25 | — | — | EP | disclosed |