Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | CCR1 | P32246 | 3/20 | 0.46 |
| ▸ | CCR5 | P51681 | 3/20 | 0.46 |
| ▸ | CCR8 | P51685 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2378021 | 0.81 | MAPT (0.44) | MAPTLMNATP53CCR1CCR5 | |
| SCHEMBL26918441 | 0.80 | MAPT (0.47) | MAPTLMNATP53CCR1CCR5 | |
| SCHEMBL29265189 | 0.79 | MAPT (0.47) | MAPTLMNATP53KDM4ESMN1; SMN2 | |
| SCHEMBL88110 | 0.79 | LMNA (0.50) | MAPTLMNATP53CCR1CCR5 | |
| SCHEMBL29740308 | 0.79 | LMNA (0.50) | MAPTLMNATP53CCR1CCR5 | |
| SCHEMBL29740307 | 0.78 | LMNA (0.48) | MAPTLMNATP53CCR1CCR5 | |
| SCHEMBL30677861 | 0.77 | PI4KA (0.42) | MAPTLMNATP53CCR1CCR5 | |
| SCHEMBL29565883 | 0.76 | PARP1 (0.50) | MAPTLMNATP53CCR1CCR5 | |
| SCHEMBL8544920 | 0.76 | LMNA (0.50) | MAPTLMNATP53CCR1CCR5 | |
| SCHEMBL31064745 | 0.76 | MAPT (0.55) | MAPTLMNATP53CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011697-A | Applying tryptophane | AMERICAN HEALTH FOUNDATION (US) | 1991-04-30 | — | — | US | disclosed |