Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | EBP | Q15125 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9804652 | 0.80 | CTDSP1 (0.32) | CTDSP1CYP2D6 | |
| SCHEMBL13271382 | 0.77 | CYP2D6 (0.44) | EBPSIGMAR1CCR1ATMCYP2D6 | |
| SCHEMBL9804889 | 0.77 | CYP1A2 (0.37) | CYP1A2EBPSIGMAR1CCR1ATM | |
| SCHEMBL10625675 | 0.76 | ATM (0.47) | CYP1A2EBPSIGMAR1CCR1ATM | |
| SCHEMBL9804779 | 0.75 | CCR1 (0.36) | CTDSP1EBPSIGMAR1CCR1 | |
| SCHEMBL9804758 | 0.74 | CYP2D6 (0.31) | CYP2D6 | |
| SCHEMBL9804896 | 0.72 | ATM (0.37) | CYP1A2EBPSIGMAR1CCR1ATM | |
| SCHEMBL9804906 | 0.71 | CCR1 (0.34) | CCR1GRIN2B | |
| SCHEMBL9804854 | 0.71 | CASP1 (0.32) | CTDSP1 | |
| SCHEMBL11630708 | 0.68 | CCR1 (0.45) | EBPSIGMAR1CCR1ATMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276920-B1 | (2-CYANO-2-(PHENYL OR NAPHTHYL)-2-SUBSTITUTED-ETHYL) PYRAZINES, PYRIMIDINES AND PYRIDAZINES | ROHM AND HAAS COMPANY (US) | 1991-04-03 | — | — | EP | disclosed |
| EP-0276920-A1 | (2-Cyano-2-(phenyl or naphthyl)-2-substituted-ethyl) pyrazines, pyrimidines and pyridazines | ROHM AND HAAS COMPANY (US) | 1988-08-03 | — | — | EP | disclosed |