Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Ethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene Glycol SCHEMBL22007 | 0.91 | — | — | |
| Ethylene Glycol SCHEMBL8082558 | 0.91 | TSHR (0.56) | TSHRMEN1KMT2AALDH1A1MAPK1 | |
| Ethylene Glycol SCHEMBL6570599 | 0.91 | TSHR (0.56) | TSHRMEN1KMT2AALDH1A1MAPK1 | |
| Ethylene Glycol SCHEMBL9616343 | 0.91 | TSHR (0.56) | TSHRMEN1KMT2AALDH1A1MAPK1 | |
| Ethylene Glycol SCHEMBL15995529 | 0.91 | TSHR (0.56) | TSHRMEN1KMT2AALDH1A1MAPK1 | |
| Ethylene Glycol SCHEMBL8080969 | 0.91 | TSHR (0.56) | TSHRMEN1KMT2AALDH1A1MAPK1 | |
| Ethylene Glycol SCHEMBL27583536 | 0.86 | — | — | |
| Ethylene Glycol SCHEMBL27449247 | 0.86 | — | — | |
| Ethylene Glycol SCHEMBL9771291 | 0.86 | — | — | |
| Ethylene Glycol SCHEMBL27305226 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894232-A | Asymmetric synthesis method of nickel-catalyzed carbon-based alpha-ester | 南京师范大学 | 2023-04-04 | — | — | CN | disclosed |
| US-8461072-B2 | Late transition metal catalysts for olefin oligomerizations | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-7994086-B2 | Late transition metal catalysts for olefin oligomerizations | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2011-08-09 | — | — | US | disclosed |
| US-20110092658-A1 | Late Transition Metal Catalysts for Olefin Oligomerizations | EXXONMOBIL CHEMICAL PATENTS INC. | 2011-04-21 | — | — | US | disclosed |
| US-7910272-B2 | Dye-containing photosensitive composition, color filter using the same, and production method thereof | FUJIFILM CORPORATION (JP) | 2011-03-22 | — | — | US | disclosed |
| US-7871953-B2 | Late transition metal catalysts for olefin oligomerizations | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-20070190435-A1 | Dye-containing photosensitive composition, color filter using the same, and production method thereof | FUJIFILM CORPORATION (JP) | 2007-08-16 | — | — | US | disclosed |
| US-20070184366-A1 | DYE CONTAINING CURABLE COMPOSITION, COLOR FILTER, AND PROCESS OF PREPARING COLOR FILTER | FUJIFILM CORPORATION | 2007-08-09 | — | — | US | disclosed |
| EP-1603929-B1 | SOLUBLE GROUP-10 ALPHA-DIIMINE CATALYST PRECURSORS | EXXONMOBIL CHEM PATENTS INC (US) | 2007-08-01 | — | — | EP | disclosed |
| US-20070099096-A1 | Dye-containing curable composition, color filter and method of producing thereof | FUJIFILM CORPORATION | 2007-05-03 | — | — | US | disclosed |
| EP-1513854-A1 | SOLUBLE LATE TRANSITION METAL CATALYSTS FOR OLEFIN OLIGOMERIZATIONS | Exxonmobil Chemical Patents Inc. (US) | 2005-03-16 | — | — | EP | disclosed |
| US-20050003955-A1 | Late transition metal catalysts for olefin oligomerizations | EXXONMOBIL CHEMICAL PATENTS INC. | 2005-01-06 | — | — | US | disclosed |
| WO-2004083224-A1 | SOLUBLE GROUP-10 α-DIIMINE CATALYST PRECURSORS, | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2004-09-30 | — | — | WO | disclosed |
| US-20040185372-A1 | Dye-containing curable composition, color filter, and process of preparing color filter | FUJI PHOTO FILM CO., LTD. | 2004-09-23 | — | — | US | disclosed |
| US-20040186010-A1 | Soluble group-10 alpha-diimine catalyst precursors, catalysts and methods for dimerizing and oligomerizing olefins | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-09-23 | — | — | US | disclosed |
| US-20040138056-A1 | Late transition metal catalysts for olefin oligomerizations | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-07-15 | — | — | US | disclosed |
| WO-2004037837-A1 | LATE TRANSITION METAL CATALYSTS FOR OLEFIN OLIGOMERIZATIONS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2004-05-06 | — | — | WO | disclosed |
| WO-2004037869-A2 | LATE TRANSITION METAL CATALYSTS FOR OLEFIN OLIGOMERIZATIONS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2004-05-06 | — | — | WO | disclosed |
| US-20040039238-A1 | Soluble late transition metal catalysts for olefin oligomerizations II | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-02-26 | — | — | US | disclosed |
| WO-2003102005-A1 | SOLUBLE LATE TRANSITION METAL CATALYSTS FOR OLEFIN OLIGOMERIZATIONS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138056-A1 | Late transition metal catalysts for olefin oligomerizations | OCIAD2, COG4, SOD1 | TSHR 4603/4885MEN1 3948/4885LMNA 4296/4885 |
| US-20040039238-A1 | Soluble late transition metal catalysts for olefin oligomerizations II | OCIAD2, ORAI2, SPINT2 | TSHR 4220/4885MEN1 3767/4885LMNA 4018/4885 |
| US-20040186010-A1 | Soluble group-10 alpha-diimine catalyst precursors, catalysts and methods for dimerizing and oligomerizing olefins | OCIAD1, COG7, OCIAD2 | TSHR 4342/4885MEN1 1474/4885LMNA 3036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.