Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F known ✓ | O60840 | 10/20 | 0.53 |
| ▸ | CACNA1D known ✓ | Q01668 | 10/20 | 0.53 |
| ▸ | CACNA1S known ✓ | Q13698 | 10/20 | 0.53 |
| ▸ | CACNA1C known ✓ | Q13936 | 10/20 | 0.53 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9808227 | 1.00 | CACNA1F (0.53) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL9501221 | 0.95 | CACNA1F (0.58) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL9505205 | 0.95 | CACNA1F (0.58) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| Fumaric Acid SCHEMBL9808384 | 0.91 | CACNA1F (0.56) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| Fumaric Acid SCHEMBL9808380 | 0.91 | CACNA1F (0.56) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| Fumaric Acid SCHEMBL9502328 | 0.88 | HIF1A (0.68) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| Fumaric Acid SCHEMBL7414367 | 0.88 | HIF1A (0.68) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7414304 | 0.86 | CACNA1F (0.59) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL9504229 | 0.85 | CACNA1F (0.62) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL9338294 | 0.85 | CACNA1F (0.62) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021436-A | Antiulcer, anticoagulant, antiischaemic agent | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1991-06-04 | — | — | US | disclosed |
| US-4999362-A | Hypotensive, Antiulcer, Cytoprotective, Antithrombotic Agents | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1991-03-12 | — | — | US | disclosed |