Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9808937 | 0.81 | MAPT (0.55) | TSHRCYP3A4ALDH1A1TDP1ALOX15 | |
| SCHEMBL9808893 | 0.80 | TDP1 (0.48) | TSHRCYP3A4ALDH1A1TDP1ALOX15 | |
| SCHEMBL9808901 | 0.80 | MEN1 (0.42) | ALDH1A1TDP1MEN1KMT2AKCNH2 | |
| SCHEMBL9808897 | 0.76 | MEN1 (0.38) | TDP1MEN1KMT2AKCNH2 | |
| SCHEMBL9808954 | 0.76 | CYP3A4 (0.41) | TSHRCYP3A4ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL9629038 | 0.74 | ALDH1A1 (0.52) | TSHRCYP3A4ALDH1A1TDP1ALOX15 | |
| SCHEMBL9808925 | 0.73 | ALKBH3 (0.36) | TSHRCYP3A4ALDH1A1TDP1ALOX15 | |
| SCHEMBL9808924 | 0.73 | TSHR (0.35) | TSHRCYP3A4ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL9808898 | 0.73 | MAPT (0.38) | TSHRCYP3A4ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL10452553 | 0.71 | DHFR (0.47) | TSHRALDH1A1MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985463-A | Aminodiaryl sulfoxide derivatives, process for their preparation and pharmaceutical and pesticidal compositions containing them | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1991-01-15 | — | — | US | disclosed |
| US-4831194-A | Process for the preparation of nitrodiaryl sulfoxides | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1989-05-16 | — | — | US | disclosed |
| US-4710323-A | Nitrodiaryl sulfoxide derivatives, process for their preparation and pharmaceutical and pesticidal compositions containing them as active ingredient | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1987-12-01 | — | — | US | disclosed |