Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 2/20 | 0.45 |
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.42 |
| ▸ | F2 | P00734 | 4/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10702473 | 0.91 | POLB (0.47) | POLBCA1CA2CA12CA9 | |
| SCHEMBL10698745 | 0.90 | POLB (0.46) | POLBCA1CA2CA12CA9 | |
| SCHEMBL10697987 | 0.88 | PRSS1 (0.45) | POLBCA1CA2CA12CA9 | |
| SCHEMBL10700833 | 0.88 | PRSS1 (0.45) | POLBCA1CA2CA12CA9 | |
| SCHEMBL1206152 | 0.87 | CA1 (0.49) | POLBCA1CA2CA12CA9 | |
| SCHEMBL10699417 | 0.86 | SCN5A (0.46) | POLBCA1CA2CA12CA9 | |
| SCHEMBL22661373 | 0.86 | POLB (0.50) | POLBCA1CA2CA12CA9 | |
| SCHEMBL21659729 | 0.83 | POLB (0.68) | POLBCA1CA2CA12CA9 | |
| SCHEMBL22940491 | 0.83 | POLB (0.72) | POLBCA1CA2CA12CA9 | |
| SCHEMBL23619645 | 0.82 | CA1 (0.47) | POLBCA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040563-B2 | Dual inhibitors of farnesyltransferase and geranylgeranyltransferase I | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-20130190355-A1 | DUAL INHIBITORS OF FARNESYLTRANSFERASE AND GERANYLGERANYLTRANSFERASE I | YALE UNIVERSITY (US) | 2013-07-25 | — | — | US | disclosed |
| EP-0283563-B1 | NOVEL DERIVATIVES | BEECHAM GROUP PLC (GB) | 1991-05-29 | — | — | EP | disclosed |
| EP-0155388-B1 | ENZYME-PROTEIN CONJUGATE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL USE THEREOF | BEECHAM GROUP PLC (GB) | 1989-03-29 | — | — | EP | disclosed |
| EP-0283563-A2 | Novel derivatives | BEECHAM GROUP PLC (GB) | 1988-09-28 | — | — | EP | disclosed |
| US-4741903-A | Novel enzyne derivatives | BEECHAM GROUP P.L.C. (GB) | 1988-05-03 | — | — | US | disclosed |
| US-4730050-A | Novel enzyme derivatives | BEECHAM GROUP P.L.C. (GB) | 1988-03-08 | — | — | US | disclosed |
| US-4600580-A | Novel enzyme derivatives | BEECHAM GROUP P.L.C. (GB) | 1986-07-15 | — | — | US | disclosed |
| EP-0155388-A2 | Enzyme-protein conjugate, process for its preparation and pharmaceutical use thereof | BEECHAM GROUP PLC (GB) | 1985-09-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190355-A1 | DUAL INHIBITORS OF FARNESYLTRANSFERASE AND GERANYLGERANYLTRANSFERASE I | FNTA, FNTB, GDI1 | POLB 2452/4885CA1 3559/4885CA2 2994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.