Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11215888 | 1.00 | BCHE (0.32) | BCHEACHEHRH4ALDH1A1 | |
| SCHEMBL9809757 | 1.00 | BCHE (0.32) | BCHEACHEHRH4ALDH1A1 | |
| SCHEMBL11527369 | 0.89 | HRH4 (0.35) | BCHEACHEHRH4 | |
| SCHEMBL11527367 | 0.89 | HRH4 (0.35) | BCHEACHEHRH4 | |
| SCHEMBL9777093 | 0.82 | HRH4 (0.32) | HRH4ALDH1A1 | |
| SCHEMBL9777091 | 0.82 | HRH4 (0.32) | HRH4ALDH1A1 | |
| SCHEMBL11527452 | 0.81 | HRH4 (0.47) | BCHEACHEHRH4 | |
| SCHEMBL11527451 | 0.81 | HRH4 (0.47) | BCHEACHEHRH4 | |
| SCHEMBL6351490 | 0.80 | — | — | |
| SCHEMBL10567402 | 0.80 | HRH4 (0.31) | HRH4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0046635-B1 | PROCESS FOR THE PREPARATION OF CIMETIDINE | ORION-YHTYMÄ OY (FI) | 1985-07-03 | — | — | EP | claimed |
| EP-0046635-A1 | Process for the preparation of cimetidine | ORION-YHTYMÄ OY (FI) | 1982-03-03 | — | — | EP | claimed |
| JP-63045266-A | — | — | None | — | — | JP | disclosed |
| JP-59190973-A | — | — | None | — | — | JP | disclosed |
| JP-59128375-A | — | — | None | — | — | JP | disclosed |
| JP-58188855-A | — | — | None | — | — | JP | disclosed |
| EP-0261818-B1 | PROCESS FOR PREPARATION OF GUANIDINE DERIVATIVE | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1991-12-11 | — | — | EP | disclosed |
| EP-0259140-B1 | CYANOGUANIDINE DERIVATIVE AND PROCESS FOR PREPARATION THEREOF | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1991-05-29 | — | — | EP | disclosed |
| US-4973703-A | ACTIVATED CARBON IN WATER IN PRESENCE OR ORGANIC ACID | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1990-11-27 | — | — | US | disclosed |
| US-4814500-A | ANTIULCER | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1989-03-21 | — | — | US | disclosed |
| US-4808726-A | REACTING N-CYANO-N*-METHYL-N\"-(2-(BUTANE-2,3-DIONYL) THIOETHYL) GUANIDINE WITH AMMONIUM SALT OF A CARBOXYLIC ACID AND FORMALDEHYDE | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1989-02-28 | — | — | US | disclosed |
| JP-S59128375-A | PREPARATION OF IMIDAZOLE COMPOUND | TOKAWA TETSUO | 1984-07-24 | — | — | JP | disclosed |
| US-4447621-A | Use of N-cyano-N'-methyl-N\"-[2-(5-methyl-4-imidazolylmethyldithio)ethyl]guanidine in the preparation of cimetidine | SK&F LAB CO. (US) | 1984-05-08 | — | — | US | disclosed |
| JP-S58188855-A | PREPARATION OF GUANIDINE DERIVATIVE | FUJIMOTO SEIYAKU KK | 1983-11-04 | — | — | JP | disclosed |
| US-4374996-A | Disulfide intermediate for cimetidine | SK & F LAB CO. (US) | 1983-02-22 | — | — | US | disclosed |
| US-4365067-A | Method for preparing pharmacologically active cyanoguanidine derivative | FUJIMOTO PHARMACEUTICAL CORPORATION (JP) | 1982-12-21 | — | — | US | disclosed |
| US-4365067-A | Method for preparing pharmacologically active cyanoguanidine derivative | FUJIMOTO PHARMACEUTICAL CORPORATION (JP) | 1982-12-21 | — | — | US | disclosed |
| EP-0046635-A1 | Process for the preparation of cimetidine | ORION-YHTYMÄ OY (FI) | 1982-03-03 | — | — | EP | disclosed |
| EP-0046635-A1 | Process for the preparation of cimetidine | ORION-YHTYMÄ OY (FI) | 1982-03-03 | — | — | EP | disclosed |
| US-4171325-A | Chemical process | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-10-16 | — | — | US | disclosed |