Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ANPEP | P15144 | 2/20 | 0.49 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3585774 | 1.00 | KDM4E (0.50) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL2801217 | 0.83 | KDM4E (0.54) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL11437981 | 0.82 | KDM4E (0.48) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL29100048 | 0.81 | KDM4E (0.50) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| Formic Acid SCHEMBL3582950 | 0.80 | ANPEP (0.46) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL28080703 | 0.78 | KDM4E (0.52) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL18230768 | 0.73 | ANPEP (0.39) | KDM4EANPEPERAP2SMN1; SMN2EPHX1 | |
| SCHEMBL31075478 | 0.73 | ANPEP (0.39) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL1443685 | 0.72 | KDM4E (0.56) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL3154036 | 0.72 | KDM4E (0.68) | KDM4EANPEPERAP2SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0424385-A1 | LIPOPHILIC POLYAMINES USEFUL FOR TREATING HYPERCHOLESTEROLEMIA | THE UPJOHN COMPANY (US) | 1991-05-02 | — | — | EP | claimed |
| WO-1989008098-A2 | LIPOPHILIC POLYAMINES USEFUL FOR TREATING HYPERCHOLESTEROLEMIA | THE UPJOHN COMPANY (US) | 1989-09-08 | — | — | WO | claimed |