Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 7/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223991 | 0.87 | DRD2 (0.57) | DRD2HTR1AHTR2ADRD3DRD1 | |
| SCHEMBL9811433 | 0.87 | DRD2 (0.46) | DRD2DRD3SLC18A3MCHR1 | |
| SCHEMBL9298267 | 0.86 | SLC18A3 (0.57) | DRD2PRCPSLC18A3HTR7 | |
| SCHEMBL9811543 | 0.85 | DRD4 (0.49) | DRD2PRCPSLC18A3 | |
| SCHEMBL9811461 | 0.84 | HRH3 (0.46) | DRD2PRCPSLC18A3 | |
| SCHEMBL9811460 | 0.84 | DRD2 (0.60) | DRD2CCR2 | |
| SCHEMBL6222615 | 0.81 | DRD2 (0.49) | DRD2HTR1AHTR2ADRD3CCR2 | |
| SCHEMBL9811498 | 0.80 | ALDH1A1 (0.53) | DRD2HTR1AHTR2ADRD3DRD1 | |
| SCHEMBL9811419 | 0.80 | CCR2 (0.40) | DRD2CCR2PRCPSLC18A3 | |
| SCHEMBL6221175 | 0.79 | SLC18A3 (0.55) | DRD2SLC18A3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272208-B1 | AROMATICALLY SUBSTITUTED AZACYCLO-ALKYLALKANEDIPHOSPHONIC ACIDS | CIBA-GEIGY AG (CH) | 1991-06-12 | — | — | EP | claimed |
| EP-0272208-B1 | AROMATICALLY SUBSTITUTED AZACYCLO-ALKYLALKANEDIPHOSPHONIC ACIDS | CIBA-GEIGY AG (CH) | 1991-06-12 | — | — | EP | disclosed |
| US-4871720-A | Aromatically substituted azacycloalkyl-alkanediphosphonic acids useful for the treatment of illnesses that can be attributed to calcium metabolism disorders | CIBA-GEIGY CORPORATION (US) | 1989-10-03 | — | — | US | disclosed |