Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.62 |
| ▸ | HTR7 | P34969 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 5/20 | 0.57 |
| ▸ | DRD1 | P21728 | 5/20 | 0.57 |
| ▸ | DRD4 | P21917 | 5/20 | 0.57 |
| ▸ | DRD5 | P21918 | 5/20 | 0.57 |
| ▸ | DRD3 | P35462 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15779804 | 0.93 | DRD2 (0.76) | DRD2KCNH2SIGMAR1MEN1TP53 | |
| SCHEMBL27571644 | 0.93 | DRD2 (0.76) | DRD2KCNH2SIGMAR1MEN1TP53 | |
| SCHEMBL256656 | 0.91 | DRD2 (0.78) | DRD2KCNH2SIGMAR1MEN1TP53 | |
| SCHEMBL152587 | 0.87 | DRD2 (0.81) | DRD2SIGMAR1MEN1TP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL9811480 | 0.84 | HTR7 (0.70) | DRD2SIGMAR1HTR7MEN1TP53 | |
| Hydrochloric Acid SCHEMBL10593224 | 0.84 | HTR7 (0.70) | DRD2SIGMAR1HTR7MEN1TP53 | |
| SCHEMBL24755587 | 0.84 | DRD1 (0.70) | DRD2KCNH2SIGMAR1MEN1TP53 | |
| Hydrochloric Acid SCHEMBL7259165 | 0.82 | SIGMAR1 (0.75) | DRD2SIGMAR1HTR7MEN1TP53 | |
| Hydrochloric Acid SCHEMBL10594777 | 0.81 | DRD2 (0.66) | DRD2SIGMAR1HTR7MEN1TP53 | |
| SCHEMBL7388033 | 0.81 | SLC18A3 (0.76) | DRD2SIGMAR1HTR7MEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272208-B1 | AROMATICALLY SUBSTITUTED AZACYCLO-ALKYLALKANEDIPHOSPHONIC ACIDS | CIBA-GEIGY AG (CH) | 1991-06-12 | — | — | EP | disclosed |
| EP-0272208-A1 | Aromatically substituted azacyclo-alkylalkanediphosphonic acids | CIBA-GEIGY AG (CH) | 1988-06-22 | — | — | EP | disclosed |