Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 3/20 | 0.36 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8847156 | 0.78 | MEN1 (0.38) | KDM4EMEN1KMT2ATPMTALDH1A1 | |
| SCHEMBL9812456 | 0.76 | ALDH1A1 (0.41) | KDM4EMEN1KMT2AMETAP2ALDH1A1 | |
| SCHEMBL8847544 | 0.69 | ALDH1A1 (0.39) | CSNK2A1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL8847351 | 0.67 | HCAR2 (0.32) | HCAR2NOTUMMEN1KMT2AALDH1A1 | |
| SCHEMBL3392534 | 0.66 | KDM4E (0.58) | CSNK2A1KDM4ENOTUMMEN1KMT2A | |
| SCHEMBL14152686 | 0.65 | HCAR2 (0.43) | CSNK2A1KDM4EHCAR2MEN1KMT2A | |
| SCHEMBL7820624 | 0.64 | HCAR2 (0.42) | CSNK2A1KDM4EHCAR2NOTUMMEN1 | |
| SCHEMBL13914928 | 0.64 | KDM4E (0.56) | CSNK2A1KDM4ENOTUMMEN1KMT2A | |
| SCHEMBL5029492 | 0.64 | CSNK2A1 (0.58) | CSNK2A1KDM4ENOTUMTPMTALDH1A1 | |
| SCHEMBL836705 | 0.64 | LDHA (0.39) | HCAR2NOTUMMEN1KMT2AMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259687-B1 | METHOD FOR THE PREPARATION OF PYRIDINE-2,3-DICARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1991-07-03 | — | — | EP | claimed |
| US-4816588-A | OXIDATION OF 8-SUBSTITUTED QUINOLINES | AMERICAN CYANAMID COMPANY (US) | 1989-03-28 | — | — | US | claimed |
| EP-0259687-A2 | Method for the preparation of pyridine-2,3-dicarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1988-03-16 | — | — | EP | claimed |