Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813100 | 0.77 | RAB9A (0.40) | LMNAMEN1KMT2AMAPTMAPK1 | |
| Flunarizine SCHEMBL16225927 | 0.74 | LMNA (1.00) | LMNAOPRM1MEN1KMT2AHIF1A | |
| Flunarizine SCHEMBL43440 | 0.74 | LMNA (1.00) | LMNAOPRM1MEN1KMT2AHIF1A | |
| Flunarizine SCHEMBL43441 | 0.74 | LMNA (1.00) | LMNAOPRM1MEN1KMT2AHIF1A | |
| Flunarizine SCHEMBL120168 | 0.73 | LMNA (1.00) | LMNAOPRM1MEN1KMT2AHIF1A | |
| Flunarizine SCHEMBL120169 | 0.73 | LMNA (1.00) | LMNAOPRM1MEN1KMT2AHIF1A | |
| Flunarizine SCHEMBL16226917 | 0.73 | LMNA (1.00) | LMNAOPRM1MEN1KMT2AHIF1A | |
| SCHEMBL2615163 | 0.73 | LMNA (0.97) | LMNAOPRM1MEN1KMT2AHIF1A | |
| SCHEMBL2615158 | 0.73 | LMNA (0.97) | LMNAOPRM1MEN1KMT2AHIF1A | |
| Flunarizine SCHEMBL10993579 | 0.73 | LMNA (0.97) | LMNAOPRM1MEN1KMT2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266549-B1 | CINNAMYL AMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1991-06-19 | — | — | EP | disclosed |