Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.32 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813439 | 0.85 | TAAR1 (0.35) | PPARAESR1ESR2ALDH1A1MAPK1 | |
| SCHEMBL9813438 | 0.85 | MEN1 (0.37) | ESR1ESR2TDP1MEN1KMT2A | |
| SCHEMBL10693312 | 0.82 | SPHK2 (0.31) | S1PR1S1PR3SPHK2TNNC1S1PR4 | |
| SCHEMBL9813462 | 0.82 | THRA (0.32) | S1PR1S1PR3SPHK2TNNC1S1PR4 | |
| SCHEMBL2142371 | 0.82 | PPARA (0.42) | PPARACYP4F2CYP4A11CA2TDP1 | |
| SCHEMBL10694561 | 0.79 | SPHK2 (0.31) | PPARAS1PR1S1PR3SPHK2ALDH1A1 | |
| SCHEMBL12501757 | 0.78 | TSHR (0.32) | ALDH1A1 | |
| SCHEMBL10690728 | 0.77 | ALDH1A1 (0.32) | S1PR1S1PR3SPHK2ALDH1A1CYP3A4 | |
| SCHEMBL9813460 | 0.77 | CYP4F2 (0.40) | PPARACYP4F2CYP4A11CA2TDP1 | |
| SCHEMBL9813434 | 0.74 | NPC1 (0.41) | ALDH1A1LMNACYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297768-B1 | ARYLTHIOALKYLPHENYL CARBOXYLIC ACIDS, COMPOSITIONS CONTAINING SAME AND METHOD OF USE | E.R. Squibb & Sons, Inc. (US) | 1991-07-24 | — | — | EP | disclosed |
| EP-0297768-A1 | Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use | E.R. Squibb & Sons, Inc. (US) | 1989-01-04 | — | — | EP | disclosed |
| US-4752616-A | Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use | E. R. SQUIBB & SONS, INC. (US) | 1988-06-21 | — | — | US | disclosed |