Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813610 | 1.00 | ALDH1A1 (0.71) | ALDH1A1TDP1PSMD14MAPTCLK1 | |
| SCHEMBL9813566 | 0.90 | PSMD14 (0.61) | ALDH1A1TDP1PSMD14MAPTATM | |
| SCHEMBL9813569 | 0.90 | PSMD14 (0.61) | ALDH1A1TDP1PSMD14MAPTATM | |
| Ralitoline SCHEMBL635346 | 0.84 | PSMD14 (0.55) | ALDH1A1TDP1PSMD14GAA | |
| Ralitoline SCHEMBL9813595 | 0.84 | PSMD14 (0.55) | ALDH1A1TDP1PSMD14GAA | |
| SCHEMBL10853625 | 0.83 | PSMD14 (0.60) | ALDH1A1TDP1PSMD14MAPTMEN1 | |
| SCHEMBL9813540 | 0.83 | PSMD14 (0.60) | ALDH1A1TDP1PSMD14MAPTMEN1 | |
| SCHEMBL10851899 | 0.81 | PSMD14 (0.55) | ALDH1A1TDP1PSMD14MAPTMEN1 | |
| SCHEMBL10851908 | 0.81 | PSMD14 (0.55) | ALDH1A1TDP1PSMD14MAPTMEN1 | |
| SCHEMBL9813607 | 0.81 | PSMD14 (0.51) | ALDH1A1TDP1PSMD14MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0124911-B1 | 4-OXO-THIAZOLIDIN-2-YLIDEN-ACETAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICAMENTS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM ILLNESSES CONTAINING THEM | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1991-07-31 | — | — | EP | disclosed |
| US-4563471-A | CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1986-01-07 | — | — | US | disclosed |
| EP-0124911-A2 | 4-Oxo-thiazolidin-2-yliden-acetamide derivatives, process for their preparation, and medicaments for the treatment of central nervous system illnesses containing them | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1984-11-14 | — | — | EP | disclosed |