Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL9813613 | 0.84 | LMNA (0.48) | TSHRDAONAPRTPLA2G1BATG4B | |
| Benzoic Acid SCHEMBL9813665 | 0.83 | PLA2G1B (0.40) | TSHRDAONAPRTPLA2G1BATG4B | |
| SCHEMBL9813638 | 0.80 | KDM4E (0.43) | USP2LMNAGAA | |
| Benzoic Acid SCHEMBL9813580 | 0.80 | OPRD1 (0.41) | TSHRDAONAPRTPLA2G1BATG4B | |
| Pyromellitic Acid SCHEMBL9813687 | 0.79 | CCR2 (0.36) | TSHRCCR2KMT2AMEN1CYP2D6 | |
| Pyromellitic Acid SCHEMBL10676594 | 0.79 | CCR2 (0.36) | TSHRCCR2KMT2AMEN1CYP2D6 | |
| Benzoic Acid SCHEMBL9813623 | 0.78 | OPRD1 (0.41) | TSHRDAONAPRTPLA2G1BATG4B | |
| Benzoic Acid SCHEMBL9813676 | 0.78 | CYP2D6 (0.39) | TSHRDAONAPRTPLA2G1BATG4B | |
| Benzoic Acid SCHEMBL9813692 | 0.78 | GAA (0.58) | TSHRDAONAPRTCCR2KMT2A | |
| Benzoic Acid SCHEMBL9813611 | 0.77 | CCR2 (0.38) | TSHRDAONAPRTPLA2G1BATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0163245-B1 | DERIVATIVES OF ALKYL-SUBSTITUTED 4-HYDROXY-METHYL-PIPERIDINE AND USE THEREOF AS STABILIZERS | AUSIMONT S.r.l. (IT) | 1991-07-31 | — | — | EP | disclosed |
| US-4772708-A | STABILIZERS FOR POLYMERS | AUSIMONT S.P.A. (IT) | 1988-09-20 | — | — | US | disclosed |
| EP-0163245-A2 | Derivatives of alkyl-substituted 4-hydroxy-methyl-piperidine and use thereof as stabilizers | AUSIMONT S.r.l. (IT) | 1985-12-04 | — | — | EP | disclosed |