Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707036 | 0.88 | ALDH1A1 (0.57) | SMN1; SMN2RAB9ANPC1USP2MEN1 | |
| SCHEMBL9510252 | 0.87 | ALDH1A1 (0.46) | SMN1; SMN2RAB9ANPC1USP2MEN1 | |
| Hydrochloric Acid SCHEMBL9510629 | 0.86 | ALDH1A1 (0.45) | SMN1; SMN2RAB9ANPC1USP2MEN1 | |
| SCHEMBL9814000 | 0.81 | SMN1; SMN2 (0.63) | SMN1; SMN2RAB9ANPC1USP2HSD17B10 | |
| SCHEMBL9493123 | 0.78 | MAOB (0.52) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9510294 | 0.78 | MAOB (0.51) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL9707160 | 0.78 | ALDH1A1 (0.53) | SMN1; SMN2RAB9ANPC1USP2HSD17B10 | |
| SCHEMBL9814008 | 0.76 | SMN1; SMN2 (0.70) | SMN1; SMN2RAB9ANPC1USP2HSD17B10 | |
| SCHEMBL9497169 | 0.75 | HPN (0.50) | SMN1; SMN2ALDH1A1POLBLMNAMAPT | |
| SCHEMBL8309788 | 0.75 | VCAM1 (0.55) | SMN1; SMN2ALDH1A1POLBLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4959364-A | Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides | G. D. SEARLE & CO. (US) | 1990-09-25 | — | — | US | claimed |
| EP-0190685-A2 | Heterocyclic amides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | claimed |
| US-4981853-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | G. D. SEARLE & CO. (US) | 1991-01-01 | — | — | US | disclosed |
| US-4959364-A | Method of treating inflammation, allergy, asthma and proliferative skin disease using heterocyclic amides | G. D. SEARLE & CO. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0190685-A2 | Heterocyclic amides | G.D. Searle & Co. (US) | 1986-08-13 | — | — | EP | disclosed |