Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9814113 | 0.79 | DRD1 (0.39) | DRD1ATMADRA1AKMT2AAR | |
| SCHEMBL9814134 | 0.78 | CA1 (0.51) | CA1CA2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL8586368 | 0.75 | CHRNA7 (0.47) | KMT2AMEN1HTR2A | |
| SCHEMBL9814142 | 0.74 | CHRNA7 (0.44) | KMT2AMEN1CA1CA2 | |
| SCHEMBL2776134 | 0.73 | HTR2A (0.40) | KMT2AMEN1HTR2ACA1CA2 | |
| SCHEMBL9814140 | 0.73 | PARP1 (0.49) | ADRA1AARCA1CA2 | |
| SCHEMBL10751929 | 0.72 | ADRA1A (0.40) | ADRA1AARHTR2ACA1CA2 | |
| SCHEMBL10752424 | 0.72 | DPP4 (0.32) | — | |
| SCHEMBL8857004 | 0.72 | ADRA1A (0.43) | ADRA1AARCA1CA2 | |
| SCHEMBL20478812 | 0.72 | ADRA1A (0.49) | ADRA1AAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166937-B1 | ADRENERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1991-08-28 | — | — | EP | disclosed |
| US-4634705-A | Adrenergic amidines | ABBOTT LABORATORIES (US) | 1987-01-06 | — | — | US | disclosed |
| EP-0166937-A2 | Adrenergic compounds | ABBOTT LABORATORIES (US) | 1986-01-08 | — | — | EP | disclosed |