Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL162736 | 0.90 | SRC (0.50) | ALOX5LCKFYNDAOIDO1 | |
| Hydrochloric Acid SCHEMBL11244144 | 0.88 | SRC (0.48) | ALOX5LCKFYNDAOIDO1 | |
| SCHEMBL10918696 | 0.88 | SRC (0.48) | ALOX5LCKFYNDAOIDO1 | |
| SCHEMBL31462137 | 0.82 | ALOX5 (0.49) | ALOX5LCKFYNDAOIDO1 | |
| SCHEMBL9814555 | 0.82 | ALOX5 (0.41) | ALOX5LCKFYNDAOIDO1 | |
| SCHEMBL10918695 | 0.81 | SMN1; SMN2 (0.42) | ALOX5LCKFYNDAOIDO1 | |
| SCHEMBL352655 | 0.78 | ALOX5 (0.47) | ALOX5LCKFYNDAOIDO1 | |
| SCHEMBL352654 | 0.78 | ALOX5 (0.47) | ALOX5LCKFYNDAOIDO1 | |
| SCHEMBL10759383 | 0.78 | ALOX5 (0.56) | ALOX5LCKFYNDAOIDO1 | |
| SCHEMBL4603992 | 0.78 | ALOX5 (0.51) | ALOX5LCKFYNDAOIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150984-B1 | 6-(SUBSTITUTED) METHYLENEPENICILLANIC AND 6-(SUBSTITUTED) HYDROXYMETHYLPENICILLANIC ACIDS AND DERIVATIVES THEREOF | PFIZER INC. (US) | 1991-09-11 | — | — | EP | claimed |
| US-5015473-A | Beta-lactamase inhibitors | PFIZER INC. (US) | 1991-05-14 | — | — | US | claimed |
| US-4826833-A | ANTIBIOTICS | PFIZER INC. (US) | 1989-05-02 | — | — | US | claimed |
| CN-85101572-A | Process for producing 6- (substituted) methylenepenicillanic acids, 6- (substituted) hydroxymethylpenicillanic acids and derivatives thereof | — | 1986-10-29 | — | — | CN | claimed |
| EP-0150984-A2 | 6-(Substituted) methylenepenicillanic and 6-(substituted) hydroxymethylpenicillanic acids and derivatives thereof | PFIZER INC. (US) | 1985-08-07 | — | — | EP | claimed |
| EP-0061313-B1 | BIS-ESTERS OF 1,1-ALKANEDIOLS WITH 6-BETA-HYDROXYMETHYLPENICILLANIC ACID 1,1-DIOXIDE AND BETA-LACTAM ANTIBIOTICS | PFIZER INC. (US) | 1985-01-16 | — | — | EP | claimed |
| EP-0061313-A2 | Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics | PFIZER INC. (US) | 1982-09-29 | — | — | EP | claimed |
| US-4342768-A | Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics | PFIZER INC. (US) | 1982-08-03 | — | — | US | claimed |
| CN-1017802-B | METHOD FOR PREPARING 6-(SUBSTD.) HYDROXYMETHYL-PENICILLANIC ACIDS OR 1,1-DIOXIDE AND DERIVS THEREOF | PFIZER (US) | 1992-08-12 | — | — | CN | disclosed |
| CN-1017801-B | 6- (substituted) hydroxymethyl penicillanic acids or 1, 1-dioxides and derivatives thereof | PFIZER (US) | 1992-08-12 | — | — | CN | disclosed |
| CN-1015462-B | METHOD FOR PREPARING 6-(SUBSTD.) METHYLENEPENICILLANIC ACIDS OR 1,1-DIOXIDE AND DERIVATIVES THEREOF | PFIZER (US) | 1992-02-12 | — | — | CN | disclosed |
| CN-1015461-B | METHOD FOR PREPARING 6-(SUBSTD.) METHYLENEPENICILLANIC ACID AND 1,1-DIOXIDE, AND DERIVATIVES THEREOF | PFIZER (US) | 1992-02-12 | — | — | CN | disclosed |
| EP-0150984-B1 | 6-(SUBSTITUTED) METHYLENEPENICILLANIC AND 6-(SUBSTITUTED) HYDROXYMETHYLPENICILLANIC ACIDS AND DERIVATIVES THEREOF | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-5015473-A | Beta-lactamase inhibitors | PFIZER INC. (US) | 1991-05-14 | — | — | US | disclosed |
| EP-0150984-A2 | 6-(Substituted) methylenepenicillanic and 6-(substituted) hydroxymethylpenicillanic acids and derivatives thereof | PFIZER INC. (US) | 1985-08-07 | — | — | EP | disclosed |
| EP-0061313-B1 | BIS-ESTERS OF 1,1-ALKANEDIOLS WITH 6-BETA-HYDROXYMETHYLPENICILLANIC ACID 1,1-DIOXIDE AND BETA-LACTAM ANTIBIOTICS | PFIZER INC. (US) | 1985-01-16 | — | — | EP | disclosed |
| US-4376076-A | Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide | PFIZER INC. (US) | 1983-03-08 | — | — | US | disclosed |
| EP-0061313-A2 | Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics | PFIZER INC. (US) | 1982-09-29 | — | — | EP | disclosed |
| US-4342768-A | Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics | PFIZER INC. (US) | 1982-08-03 | — | — | US | disclosed |
| US-4198406-A | Carbamoyl heterocyclicthio cephalosporins and pharmaceutical compositions formulated therewith | BEECHAM GROUP LIMITED (GB) | 1980-04-15 | — | — | US | disclosed |