Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2305731 | 0.90 | CES2 (0.50) | ALOX5CES2CES1KEAP1CYP2C19 | |
| Hydrochloric Acid SCHEMBL31462135 | 0.86 | CES2 (0.47) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL9814775 | 0.84 | CES2 (0.46) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL11630933 | 0.82 | CES2 (0.44) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL7537692 | 0.82 | ALOX5 (0.45) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL21580782 | 0.78 | ALOX5 (0.49) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL7955355 | 0.78 | CES2 (0.61) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL13163250 | 0.78 | ALOX5 (0.51) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL5027606 | 0.78 | ALOX5 (0.51) | ALOX5CES2CES1KEAP1CYP2C19 | |
| SCHEMBL1527335 | 0.78 | ALOX5 (0.47) | ALOX5CES2CES1KEAP1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150984-B1 | 6-(SUBSTITUTED) METHYLENEPENICILLANIC AND 6-(SUBSTITUTED) HYDROXYMETHYLPENICILLANIC ACIDS AND DERIVATIVES THEREOF | PFIZER INC. (US) | 1991-09-11 | — | — | EP | claimed |
| US-5015473-A | Beta-lactamase inhibitors | PFIZER INC. (US) | 1991-05-14 | — | — | US | claimed |
| US-4826833-A | ANTIBIOTICS | PFIZER INC. (US) | 1989-05-02 | — | — | US | claimed |
| EP-0150984-A2 | 6-(Substituted) methylenepenicillanic and 6-(substituted) hydroxymethylpenicillanic acids and derivatives thereof | PFIZER INC. (US) | 1985-08-07 | — | — | EP | claimed |
| EP-0061313-B1 | BIS-ESTERS OF 1,1-ALKANEDIOLS WITH 6-BETA-HYDROXYMETHYLPENICILLANIC ACID 1,1-DIOXIDE AND BETA-LACTAM ANTIBIOTICS | PFIZER INC. (US) | 1985-01-16 | — | — | EP | claimed |
| US-4407815-A | AMINO ACID DERIVATIVE ANTIBIOTICS | BEECHAM GROUP LIMITED (GB) | 1983-10-04 | — | — | US | claimed |
| EP-0061313-A2 | Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics | PFIZER INC. (US) | 1982-09-29 | — | — | EP | claimed |
| US-4342768-A | Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics | PFIZER INC. (US) | 1982-08-03 | — | — | US | claimed |
| CN-1017802-B | METHOD FOR PREPARING 6-(SUBSTD.) HYDROXYMETHYL-PENICILLANIC ACIDS OR 1,1-DIOXIDE AND DERIVS THEREOF | PFIZER (US) | 1992-08-12 | — | — | CN | disclosed |
| CN-1017801-B | 6- (substituted) hydroxymethyl penicillanic acids or 1, 1-dioxides and derivatives thereof | PFIZER (US) | 1992-08-12 | — | — | CN | disclosed |
| CN-1015462-B | METHOD FOR PREPARING 6-(SUBSTD.) METHYLENEPENICILLANIC ACIDS OR 1,1-DIOXIDE AND DERIVATIVES THEREOF | PFIZER (US) | 1992-02-12 | — | — | CN | disclosed |
| CN-1015461-B | METHOD FOR PREPARING 6-(SUBSTD.) METHYLENEPENICILLANIC ACID AND 1,1-DIOXIDE, AND DERIVATIVES THEREOF | PFIZER (US) | 1992-02-12 | — | — | CN | disclosed |
| EP-0150984-B1 | 6-(SUBSTITUTED) METHYLENEPENICILLANIC AND 6-(SUBSTITUTED) HYDROXYMETHYLPENICILLANIC ACIDS AND DERIVATIVES THEREOF | PFIZER INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-5015473-A | Beta-lactamase inhibitors | PFIZER INC. (US) | 1991-05-14 | — | — | US | disclosed |
| EP-0073100-A1 | Beta-lactam compounds, their preparation and their use | BEECHAM GROUP PLC (GB) | 1983-03-02 | — | — | EP | disclosed |
| EP-0061313-A2 | Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics | PFIZER INC. (US) | 1982-09-29 | — | — | EP | disclosed |
| US-4342768-A | Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide and beta-lactam antibiotics | PFIZER INC. (US) | 1982-08-03 | — | — | US | disclosed |
| US-4329454-A | Cephalosporin compounds | ELI LILLY AND COMPANY (US) | 1982-05-11 | — | — | US | disclosed |
| EP-0034443-A2 | Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1981-08-26 | — | — | EP | disclosed |
| EP-0028497-A1 | Beta-lactam antibiotics, their preparation and their use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-05-13 | — | — | EP | disclosed |